Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy (Q37776652)

23 August 2017

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title

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy (English)

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23 August 2017

1

Klaus Strebhardt

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20671765

13 June 2024

language of work or name

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1 August 2010

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full work available at URL

23 August 2017

http://www.nature.com/articles/nrd3184.pdf

file format

Portable Document Format

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http://www.nature.com/articles/nrd3184

13 June 2024

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Nature Reviews Drug Discovery

13 June 2024

published in

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23 August 2017

volume

9

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23 August 2017

issue

8

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23 August 2017

page(s)

643-660

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Polo-like kinases: a team in control of the division

23 August 2017

cites work

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Polo-like kinase 1: target and regulator of transcriptional control

21 January 2018

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Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1).

21 January 2018

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p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1.

21 January 2018

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Identification of an early-growth-response gene encoding a novel putative protein kinase

21 January 2018

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Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain

21 January 2018

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

21 January 2018

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Expression and phosphorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression

21 January 2018

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Microarray analysis of radiation response genes in primary human fibroblasts.

21 January 2018

1 reference

Constitutive expression of murine Sak-a suppresses cell growth and induces multinucleation

21 January 2018

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Chemosensitizing anti-cancer activity of LFM-A13, a leflunomide metabolite analog targeting polo-like kinases

21 January 2018

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Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles

21 January 2018

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A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5

21 January 2018

1 reference

Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase

21 January 2018

1 reference

A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association.

21 January 2018

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polo encodes a protein kinase homolog required for mitosis in Drosophila

21 January 2018

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Polo-like kinases: a team that plays throughout mitosis

31 March 2020

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Polo-like kinases and the orchestration of cell division

31 March 2020

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The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus

31 March 2020

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Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila

31 March 2020

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Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

31 March 2020

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Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development

31 March 2020

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Polo-like kinases: conservation and divergence in their functions and regulation

31 March 2020

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Cytokinesis: placing and making the final cut.

31 March 2020

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Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors

31 March 2020

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Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

31 March 2020

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Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

31 March 2020

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Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

31 March 2020

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Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.

31 March 2020

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Targeting polo-like kinase 1 for cancer therapy.

31 March 2020

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Paul Ehrlich's magic bullet concept: 100 years of progress

31 March 2020

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Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology

31 March 2020

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Progress in the discovery of polo-like kinase inhibitors.

31 March 2020

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Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

31 March 2020

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Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

31 March 2020

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Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells.

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Principles of cancer therapy: oncogene and non-oncogene addiction

31 March 2020

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Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.

31 March 2020

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Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk.

31 March 2020

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The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae

31 March 2020

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Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures

31 March 2020

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A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.

31 March 2020

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Polo boxes form a single functional domain that mediates interactions with multiple proteins in fission yeast polo kinase

31 March 2020

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Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

31 March 2020

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Polo-box domains confer target specificity to the Polo-like kinase family

31 March 2020

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Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

31 March 2020

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Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation

31 March 2020

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Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

31 March 2020

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Functional studies on the role of the C-terminal domain of mammalian polo-like kinase

31 March 2020

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On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

31 March 2020

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The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

31 March 2020

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Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

31 March 2020

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Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase

31 March 2020

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Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1.

31 March 2020

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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

31 March 2020

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Purification and cloning of a protein kinase that phosphorylates and activates the polo-like kinase Plx1.

31 March 2020

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Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells

31 March 2020

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Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora

31 March 2020

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Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

31 March 2020

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

31 March 2020

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FoxM1 is required for execution of the mitotic programme and chromosome stability

31 March 2020

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Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators

31 March 2020

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Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase

31 March 2020

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Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

31 March 2020

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Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation

31 March 2020

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p53 polymorphisms: cancer implications

31 March 2020

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The genetics of the p53 pathway, apoptosis and cancer therapy

31 March 2020

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Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

31 March 2020

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Normal cells, but not cancer cells, survive severe Plk1 depletion

31 March 2020

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Small interfering RNA-mediated Polo-like kinase 1 depletion preferentially reduces the survival of p53-defective, oncogenic transformed cells and inhibits tumor growth in animals

31 March 2020

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Plk1-mediated phosphorylation of Topors regulates p53 stability

31 March 2020

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Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo

31 March 2020

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Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

31 March 2020

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MDM2--master regulator of the p53 tumor suppressor protein

31 March 2020

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Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation

31 March 2020

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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

31 March 2020

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A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

31 March 2020

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Papillomaviruses and cancer: from basic studies to clinical application

31 March 2020

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Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins

31 March 2020

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Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6.

31 March 2020

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

31 March 2020

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M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex

31 March 2020

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Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression

31 March 2020

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Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

31 March 2020

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Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

31 March 2020

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Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1.

31 March 2020

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Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

31 March 2020

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Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase

31 March 2020

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Polo-like kinase-1 is a target of the DNA damage checkpoint

31 March 2020

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Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases

31 March 2020

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Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis

31 March 2020

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Polo-like kinase 1 is involved in invasion through extracellular matrix

31 March 2020

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Polo-like kinases and oncogenesis

31 March 2020

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Polo-like kinases (Plks) and cancer

31 March 2020

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Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer.

31 March 2020

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A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

31 March 2020

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Expression of PLK1 and survivin in diffuse large B-cell lymphoma

31 March 2020

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Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer

31 March 2020

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Polo-like kinase 1 as a new target for non-Hodgkin's lymphoma treatment

31 March 2020

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Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma

31 March 2020

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Expression patterns of polo-like kinase 1 in human gastric cancer.

31 March 2020

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Cell cycle dependent expression of Plk1 in synchronized porcine fetal fibroblasts.

31 March 2020

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Polo-like kinase-2 is required for centriole duplication in mammalian cells

31 March 2020

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Role of Plk2 (Snk) in mouse development and cell proliferation

31 March 2020

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The Polo kinase Plk4 functions in centriole duplication

31 March 2020

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The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity

31 March 2020

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Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

31 March 2020

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

31 March 2020

1 reference

5q-, twenty-five years later: a synopsis

31 March 2020

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Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies.

31 March 2020

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Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.

31 March 2020

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Oncomirs - microRNAs with a role in cancer

31 March 2020

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Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase

31 March 2020

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Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas

31 March 2020

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Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages

31 March 2020

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Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions

31 March 2020

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Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways

31 March 2020

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Polo-like kinase 3 is required for entry into S phase

31 March 2020

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Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity

31 March 2020

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Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis

31 March 2020

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Identification of a novel mitotic phosphorylation motif associated with protein localization to the mitotic apparatus

31 March 2020

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Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle

31 March 2020

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Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation

31 March 2020

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Fragmentation and dispersal of the pericentriolar Golgi complex is required for entry into mitosis in mammalian cells

31 March 2020

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Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence

31 March 2020

1 reference

The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.

31 March 2020

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The in vivo gene expression signature of oxidative stress

31 March 2020

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Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions

31 March 2020

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Activation of Polo-like kinase 3 by hypoxic stresses.

31 March 2020

1 reference

PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer

31 March 2020

1 reference

Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications

31 March 2020

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Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma

31 March 2020

1 reference

Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation

31 March 2020

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Late mitotic failure in mice lacking Sak, a polo-like kinase.

31 March 2020

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SAK/PLK4 is required for centriole duplication and flagella development

31 March 2020

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SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing

31 March 2020

1 reference

A physical map of 30,000 human genes

31 March 2020

1 reference

Multiple genetic alterations, 4q28, a new suppressor region, and potential gender differences in human hepatocellular carcinoma

31 March 2020

1 reference

Sak kinase gene structure and transcriptional regulation

31 March 2020

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Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer

31 March 2020

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Aurora-kinase inhibitors as anticancer agents

31 March 2020

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Emerging cancer therapeutic opportunities by inhibiting mitotic kinases

31 March 2020

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Progress in the evaluation of CDK inhibitors as anti-tumor agents

31 March 2020

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Cell cycle kinases as therapeutic targets for cancer

31 March 2020

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Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

31 March 2020

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Conditional inhibition of cancer cell proliferation by tetracycline-responsive, H1 promoter-driven silencing of PLK1.

31 March 2020

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Tumor inhibition by genomically integrated inducible RNAi-cassettes

31 March 2020

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The protein kinase complement of the human genome

31 March 2020

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High-throughput kinase profiling as a platform for drug discovery

31 March 2020

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Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity

31 March 2020

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Structure of the catalytic domain of human polo-like kinase 1

31 March 2020

1 reference

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

31 March 2020

1 reference

Selectivity-determining residues in Plk1

31 March 2020

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Pharmacophore modeling and virtual screening for designing potential PLK1 inhibitors.

31 March 2020

1 reference

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

31 March 2020

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Probing cell-division phenotype space and Polo-like kinase function using small molecules

31 March 2020

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Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis

31 March 2020

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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

31 March 2020

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PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint

31 March 2020

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Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors

31 March 2020

1 reference

Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).

31 March 2020

1 reference

Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions

31 March 2020

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A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1.

31 March 2020

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Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting

31 March 2020

1 reference

Thymoquinone: a promising anti-cancer drug from natural sources

31 March 2020

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Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer

31 March 2020

1 reference

A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis

31 March 2020

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Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

31 March 2020

1 reference

Inhibition of oncogene product enzyme activity as an approach to cancer chemoprevention. Tyrosine-specific protein kinase inhibition by purpurogallin from Quercus sp. nutgall

31 March 2020

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Biological activity of purpurogallin

31 March 2020

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Targeted anti-mitotic therapies: can we improve on tubulin agents?

31 March 2020

1 reference

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

31 March 2020

1 reference

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

31 March 2020

1 reference

Phase I study of ON 01910.Na, a novel modulator of the Polo-like kinase 1 pathway, in adult patients with solid tumors.

31 March 2020

1 reference

Evaluation of the novel mitotic modulator ON 01910.Na in pancreatic cancer and preclinical development of an ex vivo predictive assay.

31 March 2020

1 reference

A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors.

31 March 2020

1 reference

Discovery of thiophene inhibitors of polo-like kinase

31 March 2020

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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.

31 March 2020

1 reference

A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies

31 March 2020

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Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia.

31 March 2020

1 reference

Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors

31 March 2020

1 reference

Phase I dose escalation and pharmacokinetic study of BI 2536, a novel Polo-like kinase 1 inhibitor, in patients with advanced solid tumors.

31 March 2020

1 reference

BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity

31 March 2020

1 reference

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

31 March 2020

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Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay

31 March 2020

1 reference

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

31 March 2020

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Effect of trastuzumab-modified antisense oligonucleotide-loaded human serum albumin nanoparticles prepared by heat denaturation.

31 March 2020

1 reference

Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression.

31 March 2020

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Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin

31 March 2020

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Regulation of protein kinases; controlling activity through activation segment conformation

31 March 2020

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The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

31 March 2020

1 reference

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization

31 March 2020

1 reference

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

31 March 2020

1 reference

The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization

31 March 2020

1 reference

Polo-like kinase 1 is essential for early embryonic development and tumor suppression

31 March 2020

1 reference

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

31 March 2020

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Regulation of gene expression at the beginning of mammalian development.

31 March 2020

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Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.

31 March 2020

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Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation

31 March 2020

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Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome

31 March 2020

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The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

31 March 2020

1 reference

Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts

31 March 2020

1 reference

The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase

31 March 2020

1 reference

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

31 March 2020

1 reference

The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs

31 March 2020

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Active cyclin B1-Cdk1 first appears on centrosomes in prophase

31 March 2020

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Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

31 March 2020

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Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

31 March 2020

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Restarting the cell cycle when the checkpoint comes to a halt

31 March 2020

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Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions

31 March 2020

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Complex formation of Plk1 and INCENP required for metaphase-anaphase transition

31 March 2020

1 reference

Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1

31 March 2020

1 reference

Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores

31 March 2020

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The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase

31 March 2020

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Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

31 March 2020

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Shugoshin collaborates with protein phosphatase 2A to protect cohesin

31 March 2020

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PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

31 March 2020

1 reference

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

31 March 2020

1 reference

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

31 March 2020

1 reference

Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis

31 March 2020

1 reference

The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.

31 March 2020

1 reference

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

31 March 2020

1 reference

Segregating sister genomes: the molecular biology of chromosome separation

31 March 2020

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Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast

31 March 2020

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Preferential cleavage of chromatin-bound cohesin after targeted phosphorylation by Polo-like kinase

31 March 2020

1 reference

Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity

31 March 2020

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Cell cycle regulation of central spindle assembly.

31 March 2020

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Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells

31 March 2020

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Polo-like kinase controls vertebrate spindle elongation and cytokinesis

31 March 2020

1 reference

Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.

31 March 2020

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Polo-like Kinase 1 Triggers the Initiation of Cytokinesis in Human Cells by Promoting Recruitment of the RhoGEF Ect2 to the Central Spindle

31 March 2020

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Mitotic activation of the kinase Aurora-A requires its binding partner Bora

31 March 2020

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Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

31 March 2020

1 reference

Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism

31 March 2020

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12 December 2020

Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck

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12 December 2020

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12 December 2020

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12 December 2020

HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y

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12 December 2020

p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

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12 December 2020

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

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12 December 2020

The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB

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12 December 2020

Efficient internalization of the polo-box of polo-like kinase 1 fused to an Antennapedia peptide results in inhibition of cancer cell proliferation

1 reference

12 December 2020

Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]

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12 December 2020

Oncogenic effect of Polo-like kinase 1 expression in human gastric carcinomas

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12 December 2020

Polo-like kinase, a novel marker for cellular proliferation.

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12 December 2020

Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3.

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12 December 2020

Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function

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12 December 2020

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1999

1 reference

13 June 2024

107

58

396

SH Khan

1998

1 reference

13 June 2024

127

60

6826

CW Conn

2000

1 reference

13 June 2024

150

62

4186

J Yuan

2002

1 reference

13 June 2024

189

63

6942

H Tanaka

2003

1 reference

13 June 2024

Identifiers

DOI

10.1038/NRD3184

1 reference

23 August 2017

1 reference