Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3 (Q27670941)

1

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Mark Brown

2

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Frances Park

3

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Spencer Emtage

4

0 references

June Harriss

5

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Chhaya Das

6

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Li Zhu

7

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Andy Crew

8

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Lee Arnold

9

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Salam Shaaban

10

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Philip Tucker

Creative Commons Attribution 4.0 International

11

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language of work or name

English

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publication date

2011

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published in

PLOS One

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volume

6

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issue

7

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page(s)

e22290

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copyright license

start time

14 July 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding

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Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture

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Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity

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Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet

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The active site of the SET domain is constructed on a knot

20 March 2017

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Structure of the SET domain histone lysine methyltransferase Clr4

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Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase

20 March 2017

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Crystal structure and functional analysis of the histone methyltransferase SET7/9

20 March 2017

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Structure and catalytic mechanism of a SET domain protein methyltransferase

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CpG-rich islands and the function of DNA methylation

20 March 2017

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m-Bop, a repressor protein essential for cardiogenesis, interacts with skNAC, a heart- and muscle-specific transcription factor

20 March 2017

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TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers

20 March 2017

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Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

20 March 2017

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A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

20 March 2017

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The epigenomics of cancer

20 March 2017

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

20 March 2017

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SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

20 March 2017

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Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex

20 March 2017

1 reference

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NSD1 is essential for early post-implantation development and has a catalytically active SET domain

20 March 2017

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Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

20 March 2017

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How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

20 March 2017

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HSP90 and the chaperoning of cancer

7 April 2017

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7 April 2017

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SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation

7 April 2017

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PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression

29 September 2017

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The multiple facets of histone H4-lysine 20 methylation

29 September 2017

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Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity

29 September 2017

1 reference

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Histone lysine methyltransferases and demethylases in Plasmodium falciparum

29 September 2017

1 reference

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Preferential dimethylation of histone H4 lysine 20 by Suv4-20

29 September 2017

1 reference

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Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells

29 September 2017

1 reference

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Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle

29 September 2017

1 reference

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Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

29 September 2017

1 reference

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Hsp90--from signal transduction to cell transformation.

29 September 2017

1 reference

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Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation.

29 September 2017

1 reference

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Trithorax-group protein ASH1 methylates histone H3 lysine 36.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136521

Alterations to nuclear architecture and genome behavior in senescent cells

29 September 2017

1 reference

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Epigenetic aberrations and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136521

SET domain protein lysine methyltransferases: Structure, specificity and catalysis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136521

SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136521

Enhanced SMYD3 expression is essential for the growth of breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136521

A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136521

Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma

29 September 2017

1 reference

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TMS1/ASC: the cancer connection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136521

ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3

29 September 2017

1 reference

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29 September 2017

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Structure of SET domain proteins: a new twist on histone methylation

29 September 2017

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Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1.

29 September 2017

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Preparation of nucleosome core particle from recombinant histones

29 September 2017

1 reference

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Sequence motifs and free energies of selected natural and non-natural nucleosome positioning DNA sequences.

29 September 2017

1 reference

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Cancer DNA methylation: molecular mechanisms and clinical implications

29 September 2017

1 reference

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Chromatin meets RNA polymerase II.

2 June 2018

1 reference

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Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022290

DEAF-1 function is essential for the early embryonic development of Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022290

Structure and functional analysis of the MYND domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022290

Methylation of the ASC gene promoter is associated with aggressive prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022290

Characterization of nucleosome core particles containing histone proteins made in bacteria

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21779408

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The fundamental role of epigenetic events in cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21779408

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0022290

1 reference

ADS bibcode

2011PLoSO...622290F

0 references

1 reference

1 reference

PubMed publication ID

21779408

1 reference