Accessing protein conformational ensembles using room-temperature X-ray crystallography (Q27673946)

6

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Henry van den Bedem

2

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James S Fraser

object named as

James S Fraser

1

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author name string

Avi J Samelson

3

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P Therese Lang

4

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James M Holton

5

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Tom Alber

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

27 September 2011

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published in

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volume

108

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issue

39

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page(s)

16247-52

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cites work

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Picometer-scale conformational heterogeneity separates functional from nonfunctional states of a photoreceptor protein

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Reversible lattice repacking illustrates the temperature dependence of macromolecular interactions

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The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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Molecular dynamics and protein function

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An amino acid has two sides: a new 2D measure provides a different view of solvent exposure

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The Energy Landscapes and Motions of Proteins

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Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals

7 April 2017

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Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases

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Automated electron-density sampling reveals widespread conformational polymorphism in proteins

29 September 2017

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29 September 2017

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Modeling discrete heterogeneity in X-ray diffraction data by fitting multi-conformers

29 September 2017

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Relation between native ensembles and experimental structures of proteins

29 September 2017

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New tools provide new insights in NMR studies of protein dynamics

29 September 2017

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Studies of insulin crystals at low temperatures: effects on mosaic character and radiation sensitivity

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Cryo-cooling in macromolecular crystallography: advantages, disadvantages and optimization

29 September 2017

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Simultaneous determination of protein structure and dynamics.

29 September 2017

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29 September 2017

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29 September 2017

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Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution

29 September 2017

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Effects of temperature on protein structure and dynamics: X-ray crystallographic studies of the protein ribonuclease-A at nine different temperatures from 98 to 320 K.

29 September 2017

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Temperature-dependent X-ray diffraction as a probe of protein structural dynamics

29 September 2017

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Switch-of-Function Mutants Based on Morphology Classification of Ras Superfamily Small GTPases

29 September 2017

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Cryocrystallography of ribosomal particles

2 June 2018

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Observation of decreased radiation damage at higher dose rates in room temperature protein crystallography.

2 June 2018

1 reference

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Global conformational dynamics in ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1111325108

GTPase catalysis by Ras and other G-proteins: insights from Substrate Directed SuperImposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1111325108

The Geometry of the Ribosomal Polypeptide Exit Tunnel

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1111325108

Crystalline ribonuclease A loses function below the dynamical transition at 220 K

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1111325108

Signal transduction via Ras

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21918110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thermal expansion of a protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21918110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1111325108

1 reference

598263

ADS bibcode

2011PNAS..10816247F

0 references

598263

1 reference

1 reference

1 reference