Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation (Q27675888)

2

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Jennifer T Miller

3

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Stuart F J Le Grice

4

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Wei Yang

Nature Structural & Molecular Biology

5

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language of work or name

1 reference

February 2013

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published in

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volume

20

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issue

2

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page(s)

230-6

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A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

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N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

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Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity

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The "Connection" Between HIV Drug Resistance and RNase H

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Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering

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Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance

29 September 2017

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Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

29 September 2017

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Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

29 September 2017

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HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

29 September 2017

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Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms

29 September 2017

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Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

29 September 2017

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Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase

29 September 2017

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The P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activities

29 September 2017

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Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein

29 September 2017

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Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase

29 September 2017

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Identification of structural motifs from protein coordinate data: secondary structure and first-level supersecondary structure

29 September 2017

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29 September 2017

Reverse transcription

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Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus

29 September 2017

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Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.

29 September 2017

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Retroviral Reverse Transcription and Integration: Progress and Problems

29 September 2017

1 reference

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Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973182

3DNA: a versatile, integrated software system for the analysis, rebuilding and visualization of three-dimensional nucleic-acid structures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973182

Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973182

Efavirenz accelerates HIV-1 reverse transcriptase ribonuclease H cleavage, leading to diminished zidovudine excision

2 June 2018

1 reference

Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities

21 January 2018

1 reference

Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

21 January 2018

1 reference

Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

A detailed model of reverse transcription and tests of crucial aspects

21 January 2018

1 reference

Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)

31 March 2020

1 reference

Mechanism of DNA Strand Transfer Reactions Catalyzed by HIV-1 Reverse Transcriptase

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2485

1 reference

Dimensions Publication ID

1040101392

0 references

1 reference

1 reference

PubMed publication ID

23314251

1 reference