PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis (Q27675952)

11

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author name string

Ariele Viacava Follis

1

0 references

John C Fisher

3

0 references

Mi-Kyung Yun

4

0 references

Christy R Grace

5

0 references

Amanda Nourse

6

0 references

Katherine Baran

7

0 references

Li Ou

8

0 references

Lie Min

9

0 references

Stephen W White

10

0 references

Richard W Kriwacki

PHENIX: a comprehensive Python-based system for macromolecular structure solution

12

0 references

language of work or name

1 reference

March 2013

0 references

published in

Nature Chemical Biology

0 references

volume

9

0 references

issue

3

0 references

page(s)

163-8

0 references

cites work

1 reference

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20 March 2017

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Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

20 March 2017

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Structural plasticity underpins promiscuous binding of the prosurvival protein A1

20 March 2017

1 reference

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Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

20 March 2017

1 reference

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

20 March 2017

1 reference

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Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

20 March 2017

1 reference

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

PUMA, a novel proapoptotic gene, is induced by p53

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

PUMA induces the rapid apoptosis of colorectal cancer cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

20 March 2017

1 reference

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

20 March 2017

1 reference

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Automated structure solution with the PHENIX suite

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Automated NMR structure calculation with CYANA

20 March 2017

1 reference

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UCSF Chimera--a visualization system for exploratory research and analysis

20 March 2017

1 reference

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

20 March 2017

1 reference

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Protein backbone angle restraints from searching a database for chemical shift and sequence homology

20 March 2017

1 reference

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AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

20 March 2017

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Dynamic personalities of proteins

20 March 2017

1 reference

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The dynamic energy landscape of dihydrofolate reductase catalysis

7 April 2017

1 reference

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

7 April 2017

1 reference

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

1 reference

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Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

7 April 2017

1 reference

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Cytoplasmic functions of the tumour suppressor p53.

29 September 2017

1 reference

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Sending signals dynamically

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Conformational entropy in molecular recognition by proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

NMR: prediction of protein flexibility

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

The changing landscape of protein allostery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Solution NMR-derived global fold of a monomeric 82-kDa enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

BCL-XL dimerization by three-dimensional domain swapping.

29 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1166

Heat-Induced Dimerization of BCL-xLthrough α-Helix Swapping†

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1166

Dynamic activation of an allosteric regulatory protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1166

Solution NMR studies of an intrinsically unstructured protein within a dilute, 75 kDa eukaryotic protein assembly; probing the practical limits for efficiently assigning polypeptide backbone resonances.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1166

Site-directed methyl group labeling as an NMR probe of structure and dynamics in supramolecular protein systems: applications to the proteasome and to the ClpP protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1166

Ile, Leu, and Val Methyl Assignments of the 723-Residue Malate Synthase G Using a New Labeling Strategy and Novel NMR Methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1166

An isotope labeling strategy for methyl TROSY spectroscopy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1166

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1166

Measuring protein-protein interactions by equilibrium sedimentation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3683295

The MDM2-binding region in the transactivation domain of p53 also acts as a Bcl-X(L)-binding motif

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23340338

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1166

1 reference

Dimensions Publication ID

1025598620

0 references

1 reference

1 reference

PubMed publication ID

23340338

1 reference