Allosteric inhibition of hypoxia inducible factor-2 with small molecules (Q27676596)

2

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He-Wen Ma

3

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Jason Key

4

0 references

Lei Zhang

5

0 references

Rui Chen

6

0 references

Joseph A Garcia

7

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Jacinth Naidoo

8

0 references

Jamie Longgood

9

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Doug E Frantz

10

0 references

Uttam K Tambar

11

0 references

Kevin H Gardner

12

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Richard K Bruick

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

13

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publication date

April 2013

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published in

Nature Chemical Biology

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volume

9

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issue

4

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page(s)

271-6

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cites work

1 reference

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20 March 2017

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20 March 2017

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Principles of Ligand Binding within a Completely Buried Cavity in HIF2α PAS-B

20 March 2017

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HIF-1: upstream and downstream of cancer metabolism

20 March 2017

1 reference

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Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor

20 March 2017

1 reference

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N- and C-terminal flanking regions modulate light-induced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from Avena sativa

20 March 2017

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Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways

20 March 2017

1 reference

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

20 March 2017

1 reference

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Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor

20 March 2017

1 reference

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Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation

20 March 2017

1 reference

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

20 March 2017

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

20 March 2017

1 reference

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NMR View: A computer program for the visualization and analysis of NMR data

20 March 2017

1 reference

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Overview of the CCP4 suite and current developments

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 March 2017

1 reference

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Targeting HIF-1 for cancer therapy

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Comparative protein structure modeling of genes and genomes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

The updated biology of hypoxia-inducible factor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Ligand-binding PAS domains in a genomic, cellular, and structural context

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

HIF-2alpha deletion promotes Kras-driven lung tumor development.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

A complex task? Direct modulation of transcription factors with small molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Human cancers converge at the HIF-2alpha oncogenic axis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

29 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

Structural basis of a phototropin light switch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

Von Hippel-Lindau disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

Structure and Interactions of PAS Kinase N-Terminal PAS Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3604136

An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23434853

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1185

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1185

1 reference

Dimensions Publication ID

841176

1040491797

0 references

841176

1 reference

1 reference

1 reference