Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity (Q27676766)

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20 January 2020

title

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity (English)

1 reference

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20 January 2020

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2

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20 January 2020

Oliver Rath

3

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20 January 2020

Oliver B Sutcliffe

5

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20 January 2020

Frank Kozielski

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20 January 2020

author name string

Fang Wang

1

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20 January 2020

Hung Yi Kristal Kaan

4

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20 January 2020

Simon P Mackay

6

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20 January 2020

language of work or name

English

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publication date

13 February 2012

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Journal of Medicinal Chemistry

20 January 2020

published in

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20 January 2020

volume

55

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20 January 2020

issue

4

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20 January 2020

page(s)

1511-1525

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Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5

20 January 2020

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Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer

20 March 2017

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An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

20 March 2017

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20 March 2017

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Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

20 March 2017

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Probing the links between in vitro potency, ADMET and physicochemical parameters.

29 September 2017

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A potent chemotherapeutic strategy in prostate cancer: S-(methoxytrityl)-L-cysteine, a novel Eg5 inhibitor

29 September 2017

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A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study

29 September 2017

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A potent chemotherapeutic strategy for bladder cancer: (S)-methoxy-trityl-L-cystein, a novel Eg5 inhibitor.

29 September 2017

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S-trityl-L-cysteine derivative induces caspase-independent cell death in K562 human chronic myeloid leukemia cell line

29 September 2017

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Docetaxel-resistant prostate cancer cells remain sensitive to S-trityl-L-cysteine-mediated Eg5 inhibition

29 September 2017

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29 September 2017

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Kinesin motor proteins as targets for cancer therapy

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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27 November 2018

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27 November 2018

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27 November 2018

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Synthesis and biological evaluation of l-cysteine derivatives as mitotic kinesin Eg5 inhibitors

27 November 2018

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Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition

27 November 2018

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Reductive demercuration in deprotection of trityl thioethers, trityl amines, and trityl ethers

27 November 2018

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Interdependence between physical parameters and selection of substituent groups for correlation studies

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22248262

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22248262

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ligand binding efficiency: trends, physical basis, and implications

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22248262

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM201195M

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248262%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248262%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

22248262

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22248262%20AND%20SRC:MED&resulttype=core&format=json