Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification (Q27676966)

1

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Jung-Eun Park

2

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Wen-Jian Qian

3

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Dan Lim

4

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Andrej Scharow

5

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Thorsten Berg

6

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Michael B Yaffe

7

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Kyung S Lee

8

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Terrence R Burke

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

9

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publication date

18 May 2012

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published in

ACS Chemical Biology

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volume

7

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issue

5

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page(s)

805-10

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cites work

1 reference

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Elucidation of New Binding Interactions with the Human Tsg101 Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands

20 March 2017

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From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

20 March 2017

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Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

20 March 2017

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Hydrolytic stability of hydrazones and oximes

20 March 2017

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Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization

20 March 2017

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The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

20 March 2017

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The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

20 March 2017

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Preparation of orthogonally protected (2S, 3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides

20 March 2017

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Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3.

29 September 2017

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Promiscuous aggregate-based inhibitors promote enzyme unfolding

29 September 2017

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SAR by oxime-containing peptide libraries: application to Tsg101 ligand optimization

29 September 2017

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Protected aminooxyprolines for expedited library synthesis: application to Tsg101-directed proline-oxime containing peptides

29 September 2017

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Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation

29 September 2017

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Fragment-based lead discovery

29 September 2017

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Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk.

29 September 2017

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A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1.

29 September 2017

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Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions

27 November 2018

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Targeting polo-like kinase 1 for cancer therapy.

27 November 2018

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