Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors (Q27677345)

14

0 references

Ann-Gerd Thorsell

6

0 references

Johan Weigelt

15

0 references

Tobias Karlberg

2

0 references

Elisabet Wahlberg

1

0 references

Björn Kull

11

object named as

Björn Kull

0 references

author name string

Ekaterina Kouznetsova

3

0 references

Natalia Markova

4

0 references

Antonio Macchiarulo

1

5

0 references

Ewa Pol

7

0 references

Åsa Frostell

8

0 references

Torun Ekblad

9

0 references

Delal Öncü

10

0 references

Graeme Michael Robertson

12

0 references

Roberto Pellicciari

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

13

0 references

publication date

19 February 2012

0 references

published in

Nature Biotechnology

0 references

volume

30

0 references

page(s)

283-8

0 references

issue

3

0 references

cites work

1 reference

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

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Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken

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Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide

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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

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Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

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Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor

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Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888

20 April 2017

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Zinc binding catalytic domain of human tankyrase 1

20 April 2017

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PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation

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Too many roads not taken

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

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Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

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Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

21 January 2018

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The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

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Toward specific functions of poly(ADP-ribose) polymerase-2.

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Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

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Drug resistance caused by reversion mutation

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Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

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The role of poly(ADP-ribose) polymerase-1 in CNS disease

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Poly(ADP-ribose) metabolism in brain and its role in ischemia pathology

21 January 2018

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Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases

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Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

21 January 2018

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Novel inhibitors of poly(ADP-ribose) synthetase

21 January 2018

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Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?

21 January 2018

1 reference

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

21 January 2018

1 reference

PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers

21 January 2018

1 reference

The art of the chemical probe

21 January 2018

1 reference

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

21 January 2018

1 reference

Perspective on the pipeline of drugs being developed with modulation of DNA damage as a target

21 January 2018

1 reference

Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors.

21 January 2018

1 reference

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia

21 January 2018

1 reference

Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content

21 January 2018

1 reference

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors

21 January 2018

1 reference

CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10).

21 January 2018

1 reference

Evolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes

21 January 2018

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What is principal component analysis?

21 January 2018

1 reference

Polymerization of the adenosine 5'-diphosphate ribose moiety of NAD by rat liver nuclear enzyme

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22343925

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NBT.2121

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

3322033

1017766920

0 references

Fatcat ID

release_xiuqvd2gizgijapyroujhzm5ye

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xiuqvd2gizgijapyroujhzm5ye

mapped directly with Wikidata item

24 November 2022

based on heuristic

3322033

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference