Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity (Q27678294)

4

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Philip J Kranzusch

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object named as

Philip J Kranzusch

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James M. Berger

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object named as

James M Berger

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author name string

Amy Si-Ying Lee

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

2

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publication date

30 May 2013

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published in

Cell Reports

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volume

3

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page(s)

1362-8

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issue

5

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cites work

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

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A diverse range of gene products are effectors of the type I interferon antiviral response

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

20 March 2017

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

20 March 2017

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Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase

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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

20 March 2017

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Recognition of microorganisms and activation of the immune response

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Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

7 April 2017

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DNA recognition in immunity and disease

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STING and the innate immune response to nucleic acids in the cytosol

29 September 2017

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Signaling organelles of the innate immune system

29 September 2017

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Rules of engagement: molecular insights from host-virus arms races

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Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex

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pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells

29 September 2017

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29 September 2017

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29 September 2017

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Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells

29 September 2017

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MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

2 June 2018

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20 May 2022

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Jalview Version 2--a multiple sequence alignment editor and analysis workbench

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The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

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9 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELREP.2013.05.008

Identifiers

DOI

10.1016/J.CELREP.2013.05.008

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947209

947209

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1 reference

1 reference