Evolution of a designed retro-aldolase leads to complete active site remodeling (Q27678549)

6

object named as

Nenad Ban

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author name string

Lars Giger

1

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Sami Caner

2

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Richard Obexer

3

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Peter Kast

4

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Donald Hilvert

Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59

7

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language of work or name

English

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publication date

August 2013

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published in

Nature Chemical Biology

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volume

9

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issue

8

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page(s)

494-8

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cites work

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Charge stabilization and entropy reduction of central lysine residues in fructose-bisphosphate aldolase

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Kemp elimination catalysts by computational enzyme design

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20 March 2017

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Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

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20 March 2017

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Observation of covalent intermediates in an enzyme mechanism at atomic resolution

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Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli

20 March 2017

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Immune versus natural selection: antibody aldolases with enzymic rates but broader scope

20 March 2017

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DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

20 March 2017

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Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance

20 March 2017

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20 March 2017

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Recent developments in the PHENIX software for automated crystallographic structure determination

20 March 2017

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7 April 2017

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Comparison of designed and randomly generated catalysts for simple chemical reactions

29 September 2017

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Origins of catalysis by computationally designed retroaldolase enzymes

29 September 2017

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The influence of protein dynamics on the success of computational enzyme design

29 September 2017

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29 September 2017

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29 September 2017

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Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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New algorithms and an in silico benchmark for computational enzyme design

2 June 2018

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Understanding enzyme superfamilies. Chemistry As the fundamental determinant in the evolution of new catalytic activities

2 June 2018

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An efficient benchtop system for multigram-scale kinetic resolutions using aldolase antibodies

2 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23748672

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Class I aldolases: substrate specificity, mechanism, inhibitors and structural aspects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23748672

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1276

1 reference

Dimensions Publication ID

1002653202

0 references

1 reference

1 reference

PubMed publication ID

23748672

1 reference