Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil (Q27678689)

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29 January 2020

title

Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil (English)

1 reference

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29 January 2020

main subject

Plasmodium falciparum

0 references

author

Yongyuth Yuthavong

6

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Sumalee Kamchonwongpaisan

29 January 2020

7

object named as

Sumalee Kamchonwongpaisan

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29 January 2020

author name string

Jarunee Vanichtanankul

1

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29 January 2020

Supannee Taweechai

2

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29 January 2020

Chayasith Uttamapinant

3

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29 January 2020

Penchit Chitnumsub

4

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29 January 2020

Tirayut Vilaivan

5

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29 January 2020

language of work or name

English

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publication date

23 April 2012

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Antimicrobial Agents and Chemotherapy

29 January 2020

published in

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29 January 2020

volume

56

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29 January 2020

page(s)

3928-3935

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29 January 2020

issue

7

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Trypanosomal dihydrofolate reductase reveals natural antifolate resistance

29 January 2020

cites work

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29 September 2017

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Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance

29 September 2017

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29 September 2017

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29 September 2017

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Protein volume in solution

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Studies on the Santa Lucia (El Salvador) Strain of Plasmodium falciparum in Aotus trivirgatus Monkeys

29 September 2017

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Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.

29 September 2017

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Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins

2 June 2018

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Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications.

2 June 2018

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The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.

2 June 2018

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A genome-wide map of diversity in Plasmodium falciparum

27 November 2018

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Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum

27 November 2018

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Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding.

27 November 2018

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Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum

27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22526319

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22526319

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.00301-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22526319%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22526319%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference