An ATP-site on-off switch that restricts phosphatase accessibility of Akt (Q27678970)

1

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Jie Lin

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Wen-I Wu

3

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Joshua Ballard

4

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Brian B Lee

5

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Susan L Gloor

6

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Guy P A Vigers

7

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Tony H Morales

8

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Lori S Friedman

9

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Nicholas Skelton

10

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Barbara J Brandhuber

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

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language of work or name

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8 May 2012

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published in

Science Signaling

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volume

5

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issue

223

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page(s)

ra37

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cites work

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Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 April 2017

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Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

21 April 2017

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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

21 April 2017

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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

21 April 2017

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Discovery of pyrrolopyrimidine inhibitors of Akt

21 April 2017

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

21 April 2017

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 April 2017

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Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer

21 April 2017

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

21 April 2017

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A mosaic activating mutation in AKT1 associated with the Proteus syndrome

21 April 2017

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The CCP4 suite: programs for protein crystallography

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Coot: model-building tools for molecular graphics

21 April 2017

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Rational design of inhibitors that bind to inactive kinase conformations

21 April 2017

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Perturbations of the AKT signaling pathway in human cancer

21 April 2017

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Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

21 January 2018

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Role of Akt/protein kinase B in metabolism.

21 January 2018

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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

21 January 2018

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Mechanism of activation and function of protein kinase B.

21 January 2018

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

21 January 2018

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Akt inhibitors in clinical development for the treatment of cancer

21 January 2018

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An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

21 January 2018

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Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition

21 January 2018

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Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity

21 January 2018

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Inhibitor hijacking of Akt activation

21 January 2018

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Regulation of Akt/PKB Ser473 phosphorylation

21 January 2018

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Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model

21 January 2018

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Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

21 January 2018

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Participation of ADP dissociation in the rate-determining step in cAMP-dependent protein kinase.

21 January 2018

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A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A.

21 January 2018

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

21 January 2018

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Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

21 January 2018

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Data transformation practices in biomedical sciences

21 January 2018

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Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

21 January 2018

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