Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. (Q35558850)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22031698%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity (English)

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1

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4

John M Pascal

1 reference

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15 January 2020

author name string

Jin Zhang

2

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15 January 2020

Ulrich Rodeck

3

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Roger S Armen

5

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15 January 2020

Maureen Spring

6

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15 January 2020

Calin D Dumitru

7

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15 January 2020

Valerie Myers

8

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15 January 2020

Xue Li

9

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Joseph Y Cheung

10

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15 January 2020

Arthur M Feldman

11

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15 January 2020

language of work or name

English

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publication date

26 October 2011

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Proceedings of the National Academy of Sciences of the United States of America

15 January 2020

published in

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volume

108

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issue

46

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page(s)

E1120-7

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Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis

15 January 2020

cites work

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Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells

12 July 2018

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12 July 2018

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Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

12 July 2018

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AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines

12 July 2018

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Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.

12 July 2018

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Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

12 July 2018

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Physiological roles of PKB/Akt isoforms in development and disease

12 July 2018

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Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition

12 July 2018

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A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

12 July 2018

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A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.

12 July 2018

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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

12 July 2018

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

12 July 2018

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A family with severe insulin resistance and diabetes due to a mutation in AKT2.

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

12 July 2018

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The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila

26 September 2018

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Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity

26 September 2018

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Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma.

26 September 2018

1 reference

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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

26 September 2018

1 reference

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Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

26 September 2018

1 reference

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Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1109879108

The phosphotyrosine phosphatase inhibitor vanadyl hydroperoxide induces morphological alterations, cytoskeletal rearrangements and increased adhesiveness in rat neutrophil leucocytes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22031698

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Purine nucleotide- and sugar phosphate-induced inhibition of the carboxyl methylation and catalysis of protein phosphatase-2A in insulin-secreting cells: protection by divalent cations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22031698

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1109879108

1 reference

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15 January 2020

0 references

1 reference

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15 January 2020

1 reference