Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1 (Q27679074)

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object named as

Marie-France Langelier

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John M Pascal

4

object named as

John M Pascal

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author name string

Jamie L Planck

2

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Swati Roy

The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

3

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language of work or name

English

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publication date

11 May 2012

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published in

Science

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volume

336

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issue

6082

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page(s)

728-32

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cites work

1 reference

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Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY

20 March 2017

1 reference

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A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation

20 March 2017

1 reference

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The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis

20 March 2017

1 reference

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Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling

20 March 2017

1 reference

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Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken

20 March 2017

1 reference

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

20 March 2017

1 reference

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Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif

20 March 2017

1 reference

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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

22 April 2017

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22 April 2017

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Solving structures of protein complexes by molecular replacement with Phaser

22 April 2017

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The CCP4 suite: programs for protein crystallography

22 April 2017

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Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

22 April 2017

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Coot: model-building tools for molecular graphics

22 April 2017

1 reference

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PARP inhibition: PARP1 and beyond

22 April 2017

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Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

7 April 2017

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The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

7 April 2017

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The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction

29 September 2017

1 reference

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Structural and biophysical studies of human PARP-1 in complex with damaged DNA.

29 September 2017

1 reference

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Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

29 September 2017

1 reference

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Poly(ADP-ribose) polymerase-1 dimerizes at a 5' recessed DNA end in vitro: a fluorescence study.

29 September 2017

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Mutations in the amino-terminal domain of the human poly(ADP-ribose) polymerase that affect its catalytic activity but not its DNA binding capacity.

29 September 2017

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Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins

29 September 2017

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Visualization of a DNA-PK/PARP1 complex.

29 September 2017

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Characterisation of a gain-of-function mutant of poly(ADP-ribose) polymerase.

2 June 2018

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The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription

2 June 2018

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Regulation of poly(ADP-ribose) polymerase-1 by DNA structure-specific binding

27 November 2018

1 reference

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Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22582261

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22582261

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1216338

1 reference

2026902

ADS bibcode

2012Sci...336..728L

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2026902

1 reference

1 reference

1 reference