KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry (Q27679464)

5

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author name string

Karin Betz

1

0 references

Denis A Malyshev

2

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Thomas Lavergne

3

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Tammy J Dwyer

6

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Phillip Ordoukhanian

7

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Floyd E Romesberg

8

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Andreas Marx

The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism

9

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publication date

July 2012

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published in

Nature Chemical Biology

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volume

8

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issue

7

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page(s)

612-4

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cites work

1 reference

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Solution Structure, Mechanism of Replication, and Optimization of an Unnatural Base Pair

20 March 2017

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Nanomaterials based on DNA

20 March 2017

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Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs

20 March 2017

1 reference

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

20 March 2017

1 reference

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Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet

20 March 2017

1 reference

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An unnatural hydrophobic base pair system: site-specific incorporation of nucleotide analogs into DNA and RNA

20 March 2017

1 reference

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Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

7 April 2017

1 reference

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Major groove substituents and polymerase recognition of a class of predominantly hydrophobic unnatural base pairs

7 April 2017

1 reference

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Alternative DNA base-pairs: from efforts to expand the genetic code to potential material applications.

29 September 2017

1 reference

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Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA Replication

29 September 2017

1 reference

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Transcription of an expanded genetic alphabet.

29 September 2017

1 reference

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Optimization of an unnatural base pair toward natural-like replication

29 September 2017

1 reference

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A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+).

29 September 2017

1 reference

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Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet

29 September 2017

1 reference

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Structure and mechanism of DNA polymerases

29 September 2017

1 reference

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Escherichia coli DNA polymerase I (Klenow fragment) uses a hydrogen-bonding fork from Arg668 to the primer terminus and incoming deoxynucleotide triphosphate to catalyze DNA replication.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690913

29 September 2017

DNA replication fidelity

1 reference

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Active site tightness and substrate fit in DNA replication

29 September 2017

1 reference

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Hydrogen bonding revisited: geometric selection as a principal determinant of DNA replication fidelity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690913

Fidelity mechanisms in DNA replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690913

PCR with an expanded genetic alphabet

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690913

A chemical toolkit for proteins--an expanded genetic code

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.966

A stable DNA duplex containing a non-hydrogen-bonding and non-shape-complementary base couple: interstrand stacking as the stability determining factor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22660438

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.966

1 reference

Dimensions Publication ID

1018428867

0 references

1 reference

1 reference

PubMed publication ID

22660438

1 reference