Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef (Q27681200)

1

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Rajendra Singh

2

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Stefanie Homann

3

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John Guatelli

5

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Yong Xiong

Nature Structural & Molecular Biology

6

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publication date

17 June 2012

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published in

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volume

19

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page(s)

701-6

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issue

7

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cites work

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Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit

29 September 2017

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Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.

29 September 2017

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Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2.

29 September 2017

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HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

29 September 2017

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Crystal structure of the clathrin adaptor protein 1 core

29 September 2017

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The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC.

29 September 2017

1 reference

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Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

29 September 2017

1 reference

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The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

29 September 2017

1 reference

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Refined solution structure and backbone dynamics of HIV-1 Nef.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Biochemical dissection of AP-1 recruitment onto Golgi membranes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407041

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

2 June 2018

1 reference

The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail.

21 January 2018

1 reference

Structural characterisation and functional significance of transient protein-protein interactions.

21 January 2018

1 reference

Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain

21 January 2018

1 reference

The cytoplasmic tail of the cation-independent mannose 6-phosphate receptor contains four binding sites for AP-1.

21 January 2018

1 reference

Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution.

21 January 2018

1 reference

Clathrin-associated adaptor protein complexes

21 January 2018

1 reference

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

21 January 2018

1 reference

T7 vectors with modified T7lac promoter for expression of proteins in Escherichia coli

21 January 2018

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31 March 2020

Identifiers

DOI

10.1038/NSMB.2328

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Dimensions Publication ID

40506

1007255545

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40506

1 reference

1 reference

1 reference