Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma (Q27681413)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24447275%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma (English)

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5 March 2020

0 references

He Huang

1

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5 March 2020

Huiying Li

2

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5 March 2020

Sun Yang

3

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5 March 2020

Georges Chreifi

4

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5 March 2020

Linda J Roman

6

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5 March 2020

Thomas L Poulos

8

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5 March 2020

Richard B Silverman

9

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5 March 2020

language of work or name

English

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publication date

30 January 2014

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Journal of Medicinal Chemistry

5 March 2020

published in

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5 March 2020

volume

57

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5 March 2020

issue

3

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5 March 2020

page(s)

686-700

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Structure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase

5 March 2020

cites work

1 reference

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Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations

20 March 2017

1 reference

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Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase

20 March 2017

1 reference

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Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

20 March 2017

1 reference

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Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model

20 March 2017

1 reference

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The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis

20 March 2017

1 reference

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Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines

20 March 2017

1 reference

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

20 March 2017

2 references

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20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

Nitric oxide synthases: structure, function and inhibition

29 September 2017

1 reference

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Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease

20 March 2017

1 reference

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Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.

20 March 2017

1 reference

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Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

29 September 2017

1 reference

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Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

Arginine mimetic structures in biologically active antagonists and inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

Blocking NO synthesis: how, where and why?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

Mechanism of free-radical generation by nitric oxide synthase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

Characterization of bovine endothelial nitric oxide synthase expressed in E. coli.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli

29 September 2017

1 reference

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Nitric oxide synthases: properties and catalytic mechanism

29 September 2017

1 reference

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N-methylation: potential mechanism for metabolic activation of carcinogenic primary arylamines

29 September 2017

1 reference

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First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain

29 September 2017

1 reference

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Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983353

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein

27 November 2018

1 reference

12 December 2020

Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors

1 reference

12 December 2020

1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

1 reference

12 December 2020

Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain

1 reference

12 December 2020

1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide

1 reference

12 December 2020

Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS)

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM401252E

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24447275%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

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5 March 2020

PubMed publication ID

24447275

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24447275%20AND%20SRC:MED&resulttype=core&format=json