From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes (Q27681642)

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4 June 2020

Martin P Horvath

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4 June 2020

author name string

Kigen J Curtice

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4 June 2020

Vernon D Twede

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4 June 2020

Maren Watkins

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4 June 2020

Paweł Gruszczyński

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4 June 2020

Grzegorz Bulaj

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4 June 2020

Baldomero M Olivera

8

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4 June 2020

publication date

April 2014

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number of pages

13

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inferred from page(s)

published in

Toxicon

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4 June 2020

volume

81

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4 June 2020

page(s)

67-79

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Role of gamma-carboxyglutamic acid in the calcium-induced structural transition of conantokin G, a conotoxin from the marine snail Conus geographus

4 June 2020

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Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly

20 March 2017

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20 March 2017

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20 March 2017

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μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

7 April 2017

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Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

29 September 2017

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N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse

29 September 2017

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Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors

29 September 2017

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The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.

29 September 2017

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Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads.

29 September 2017

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Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor

29 September 2017

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Integrating the discovery pipeline for novel compounds targeting ion channels

29 September 2017

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Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

29 September 2017

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Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors

29 September 2017

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Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides

29 September 2017

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Conus peptides: biodiversity-based discovery and exogenomics

29 September 2017

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Conantokins: peptide antagonists of NMDA receptors

29 September 2017

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Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous system

29 September 2017

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Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid

29 September 2017

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Glutamate-induced currents reveal three functionally distinct NMDA receptor populations in rat dorsal horn - effects of peripheral nerve lesion and inflammation

29 September 2017

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5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition

29 September 2017

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29 September 2017

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Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R.

29 September 2017

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29 September 2017

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Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors

29 September 2017

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Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors

29 September 2017

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NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia

2 June 2018

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The roles of individual gamma-carboxyglutamate residues in the solution structure and cation-dependent properties of conantokin-T.

2 June 2018

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Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: mesencephalic dopaminergic neurons

2 June 2018

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High-affinity zinc inhibition of NMDA NR1-NR2A receptors.

2 June 2018

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Conantokin-G selectively inhibits N-methyl-D-aspartate-induced currents in Xenopus oocytes injected with mouse brain mRNA.

2 June 2018

1 reference

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Anatomical localization and expression pattern for the NMDA-2D receptor subunit in a rat model of neuropathic pain

2 June 2018

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Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists

27 November 2018

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Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket

27 November 2018

1 reference

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The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor

27 November 2018

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The micromolar zinc-binding domain on the NMDA receptor subunit NR2B.

27 November 2018

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Point mutations identify the glutamate binding pocket of the N-methyl-D-aspartate receptor as major site of conantokin-G inhibition

27 November 2018

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Internal coordinates for molecular dynamics and minimization in structure determination and refinement.

27 November 2018

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Amino acid determinants for NMDA receptor inhibition by conantokin-T.

27 November 2018

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Characterization of the glutamatergic system for induction and maintenance of allodynia.

27 November 2018

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Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T.

27 November 2018

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Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor.

27 November 2018

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NMDA-receptor antagonist requirements in conantokin-G.

27 November 2018

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Expression of N-methyl-D-aspartate receptor subunit mRNAs in the human brain: striatum and globus pallidus.

27 November 2018

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Role of modified glutamic acid in the helical structure of conantokin-T.

27 November 2018

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Polyamine-like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA) antagonist

27 November 2018

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12 December 2020

The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions

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12 December 2020

5-Aminomethylquinoxaline-2,3-diones, Part III: Arylamide derivatives as highly potent and selective glycine-site NMDA receptor antagonists

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12 December 2020

N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists

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12 December 2020

Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T

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12 December 2020

Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R

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12 December 2020

10.1016/J.TOXICON.2014.01.016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24508768%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24508768%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

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