Structural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction (Q27682252)

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English	Structural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction	scientific article

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scholarly article

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Structural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction (English)

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stereoselectivity

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based on heuristic

inferred from title

author name string

Shawn K Piasecki

1

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Jianting Zheng

2

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Abram J Axelrod

3

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Madeline E Detelich

4

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Adrian T Keatinge-Clay

5

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language of work or name

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publication date

September 2014

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82

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9

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2067-77

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Structure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide Synthase

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Vinylogous chain branching catalysed by a dedicated polyketide synthase module

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Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

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Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

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Crystal structure of hexanoyl-CoA bound to β-ketoacyl reductase FabG4 of Mycobacterium tuberculosis

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Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole Synthase

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Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase

1 reference

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Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

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Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

1 reference

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Coot: model-building tools for molecular graphics

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1 reference

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Preparation of selenomethionyl proteins for phase determination

1 reference

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Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro

1 reference

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The structures of type I polyketide synthases

1 reference

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29 September 2017

Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain

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29 September 2017

Biosynthesis of polyketides by trans-AT polyketide synthases

1 reference

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29 September 2017

Type I polyketide synthases that require discrete acyltransferases

1 reference

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29 September 2017

A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth

1 reference

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29 September 2017

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.

1 reference

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Structure and mechanism of the 6-deoxyerythronolide B synthase

1 reference

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The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis

1 reference

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1 reference

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Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42.

1 reference

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Polyketide biosynthesis: a millennium review

1 reference

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A fungal ketoreductase domain that displays substrate-dependent stereospecificity

1 reference

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2 June 2018

Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142079

2 June 2018

Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase

1 reference

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2 June 2018

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

1 reference

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2 June 2018

Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase

1 reference

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4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

1 reference

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21 January 2018

bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina

1 reference

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Broad substrate specificity of ketoreductases derived from modular polyketide synthases.

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24561

21 January 2018

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24561

21 January 2018

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

1 reference

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Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum.

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24561

21 January 2018

Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24561

21 January 2018

Biosynthesis of the respiratory toxin bongkrekic acid in the pathogenic bacterium Burkholderia gladioli.

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24561

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The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

1 reference

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Substrate-dependent stereospecificity of Tyl-KR1: an isolated polyketide synthase ketoreductase domain from Streptomyces fradiae.

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24561

21 January 2018

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

1 reference

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

PksS from Bacillus subtilis is a cytochrome P450 involved in bacillaene metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/24634061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chivosazole A--elucidation of the absolute and relative configuration

1 reference

https://pubmed.ncbi.nlm.nih.gov/24634061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family

1 reference

https://pubmed.ncbi.nlm.nih.gov/24634061

12 December 2020

based on heuristic

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Stereochemical Determination of Thuggacins A–C, Highly Active Antibiotics from the MyxobacteriumSorangium cellulosum

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24634061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PROT.24561

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