Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole Synthase (Q27670570)

1

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Xi Jin

2

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Irimpan I Mathews

3

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David E Cane

I-TASSER: a unified platform for automated protein structure and function prediction

4

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language of work or name

English

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publication date

2 August 2011

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published in

Biochemistry

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volume

50

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issue

30

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page(s)

6539-48

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cites work

1 reference

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Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

20 March 2017

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Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase

20 March 2017

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20 March 2017

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Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase

20 March 2017

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Electrostatics of nanosystems: application to microtubules and the ribosome

20 March 2017

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20 March 2017

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20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Automated protein model building combined with iterative structure refinement

20 March 2017

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ESPript: analysis of multiple sequence alignments in PostScript

20 March 2017

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Improved R-factors for diffraction data analysis in macromolecular crystallography

20 March 2017

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Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases

20 March 2017

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iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.

29 September 2017

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Structures and mechanisms of polyketide synthases

29 September 2017

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FireDock: a web server for fast interaction refinement in molecular docking

29 September 2017

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Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase

29 September 2017

1 reference

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The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

29 September 2017

1 reference

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Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography

29 September 2017

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Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes.

29 September 2017

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Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

29 September 2017

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Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

29 September 2017

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Site-directed mutagenesis studies on the recombinant thioesterase domain of chicken fatty acid synthase expressed in Escherichia coli

29 September 2017

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Solution structure of Asl1650, an acyl carrier protein from Anabaena sp. PCC 7120 with a variant phosphopantetheinylation-site sequence

29 September 2017

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Introduction of a cysteine protease active site into trypsin

2 June 2018

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Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

2 June 2018

1 reference

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FireDock: fast interaction refinement in molecular docking

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144309

The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144309

Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia

27 November 2018

1 reference

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Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144309

Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144309

Malonyl-CoA:ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144309

27 November 2018

Identifiers

DOI

10.1021/BI200632J

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1 reference

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PubMed publication ID

21707057

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