Structure of the human P2Y12 receptor in complex with an antithrombotic drug (Q27682517)

17

0 references

Vadim Cherezov

16

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Kaihua Zhang

Kaihua Zhang

1

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Raymond C. Stevens

Raymond C Stevens

19

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Christa E Müller

Christa E Müller

13

0 references

Kenneth A. Jacobson

Kenneth A Jacobson

18

0 references

Zhan-Guo Gao

3

Zhan-Guo Gao

0 references

Silvia Paoletta

8

Silvia Paoletta

0 references

Gye Won Han

6

Gye Won Han

0 references

Jiang Hualiang

15

Hualiang Jiang

0 references

Gustavo Fenalti

11

Gustavo Fenalti

0 references

author name string

Jin Zhang

2

0 references

Dandan Zhang

4

0 references

Lan Zhu

5

0 references

Steven M Moss

7

0 references

Evgeny Kiselev

9

0 references

Weizhen Lu

10

0 references

Wenru Zhang

12

0 references

Huaiyu Yang

14

0 references

Beili Wu

20

0 references

Qiang Zhao

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

21

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language of work or name

English

0 references

publication date

1 May 2014

0 references

published in

Nature

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volume

509

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issue

7498

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page(s)

115-8

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cites work

1 reference

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High-resolution crystal structure of human protease-activated receptor 1

20 March 2017

1 reference

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Restructuring G-protein- coupled receptor activation

20 March 2017

1 reference

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Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174307

Crystal structure of a lipid G protein-coupled receptor

20 March 2017

1 reference

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International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

20 March 2017

1 reference

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The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts

20 March 2017

1 reference

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Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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Phasercrystallographic software

20 March 2017

1 reference

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REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use

20 March 2017

1 reference

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The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

20 March 2017

1 reference

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Ticagrelor versus clopidogrel in patients with acute coronary syndromes

7 April 2017

1 reference

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Crystallizing membrane proteins using lipidic mesophases

7 April 2017

1 reference

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Structure-function of the G protein-coupled receptor superfamily

7 April 2017

1 reference

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The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.

29 September 2017

1 reference

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Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors

29 September 2017

1 reference

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The platelet P2Y₁₂ receptor for adenosine diphosphate: congenital and drug-induced defects.

29 September 2017

1 reference

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Mutational analysis of residues important for ligand interaction with the human P2Y(12) receptor

29 September 2017

1 reference

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P2Y nucleotide receptors: promise of therapeutic applications

29 September 2017

1 reference

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Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist

29 September 2017

1 reference

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The P2 receptors and congenital platelet function defects.

29 September 2017

1 reference

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Identification of core amino acids stabilizing rhodopsin

29 September 2017

1 reference

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Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174307

Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174307

The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.

2 June 2018

1 reference

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Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation

2 June 2018

1 reference

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Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y₁₂ receptor.

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13083

Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13083

The structural evolution of a P2Y-like G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13083

Studies on the role of the extracellular cysteines and oligomeric structures of the P2Y12 receptor when interacting with antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13083

Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13083

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13083

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13083

Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174307

27 November 2018

Identifiers

DOI

10.1038/NATURE13083

1 reference

Dimensions Publication ID

1018280867

0 references

1 reference

1 reference

PubMed publication ID

24670650

1 reference