Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity (Q27683393)

GOA release 2020-03-11

author

Milton T Stubbs

7

1 reference

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13 June 2020

author name string

Christoph Parthier

1

1 reference

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13 June 2020

Marco Stelter

2

1 reference

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13 June 2020

Christian Ursel

3

1 reference

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13 June 2020

Uwe Fandrich

4

1 reference

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13 June 2020

Hauke Lilie

5

1 reference

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13 June 2020

Constanze Breithaupt

6

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

13 June 2020

language of work or name

English

0 references

publication date

29 April 2014

0 references

published in

1 reference

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13 June 2020

volume

111

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13 June 2020

issue

17

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13 June 2020

page(s)

6281-6286

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24733933%20AND%20SRC:MED&resulttype=core&format=json

Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation

13 June 2020

cites work

1 reference

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Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS

20 March 2017

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Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands

20 March 2017

1 reference

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Functional Insights from the Crystal Structure of the N-Terminal Domain of the Prototypical Toll Receptor

20 March 2017

1 reference

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Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

20 March 2017

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Structural and functional insights into lipid-bound nerve growth factors

20 March 2017

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Structural basis of TLR5-flagellin recognition and signaling

20 March 2017

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The structural biology of Toll-like receptors

20 March 2017

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

20 March 2017

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Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms

20 March 2017

1 reference

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

20 March 2017

1 reference

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

20 March 2017

1 reference

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Structure of human follicle-stimulating hormone in complex with its receptor

20 March 2017

1 reference

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A structural basis of the interactions between leucine-rich repeats and protein ligands

20 March 2017

1 reference

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

20 March 2017

1 reference

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

7 April 2017

1 reference

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The leucine-rich repeat as a protein recognition motif

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Toll receptors in innate immunity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Molecular mechanism that induces activation of Spätzle, the ligand for the Drosophila Toll receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

High level expression of the Drosophila Toll receptor ectodomain and crystallization of its complex with the morphogen Spätzle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Creating gradients by morphogen shuttling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Structural biology of the Toll-like receptor family

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Evolutionary and functional epitopes of the Spätzle protein: new insights into activation of the Toll receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

The leucine-rich repeat structure.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Structure and function of Toll receptors and their ligands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Determination of the two-dimensional interaction rate constants of a cytokine receptor complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Dorsoventral axis formation in the Drosophila embryo--shaping and transducing a morphogen gradient

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Multimerization and interaction of Toll and Spätzle in Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Signal transduction by a protease cascade

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Proteolytic processing of the Drosophila Spätzle protein by easter generates a dimeric NGF-like molecule with ventralising activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Information for the dorsal--ventral pattern of the Drosophila embryo is stored as maternal mRNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Drosophila Toll and IL-1 receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Multiple isoforms of the Drosophila Spätzle protein are encoded by alternatively spliced maternal mRNAs in the precellular blastoderm embryo.

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320678111

Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320678111

Getting knotted: a model for the structure and activation of Spätzle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320678111

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320678111

Self-organized shuttling: generating sharp dorsoventral polarity in the early Drosophila embryo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320678111

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1320678111

Spätzle regulates the shape of the Dorsal gradient in the Drosophila embryo.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036000

Structural and functional diversity in the leucine-rich repeat family of proteins

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24733933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1320678111

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24733933%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

ADS bibcode

2014PNAS..111.6281P

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24733933%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

24733933

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24733933%20AND%20SRC:MED&resulttype=core&format=json