Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands (Q27684259)

2

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Takuma Shibata

3

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Kensuke Miyake

4

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Toshiyuki Shimizu

Innate immune recognition

5

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language of work or name

English

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publication date

22 March 2013

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published in

Science

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volume

339

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page(s)

1426-9

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issue

6126

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cites work

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Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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The evolution of vertebrate Toll-like receptors

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Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

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Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

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Structural basis of TLR5-flagellin recognition and signaling

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Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

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Methods used in the structure determination of bovine mitochondrial F1 ATPase

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Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

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Coot: model-building tools for molecular graphics

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Refinement of macromolecular structures by the maximum-likelihood method

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Molecular replacement with MOLREP

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

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Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

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PHENIX: building new software for automated crystallographic structure determination

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Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

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Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization

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Activation of the mammalian immune system by siRNAs.

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

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Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

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The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

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Processing of X-ray diffraction data collected in oscillation mode

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Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

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Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4

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Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells

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