Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery (Q27683548)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24768307%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

title

Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery (English)

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16 March 2020

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Barry V L Potter

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16 March 2020

author name string

Huanchen Wang

1

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16 March 2020

Himali Y Godage

2

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16 March 2020

Jeremy D Weaver

4

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16 March 2020

Stephen B Shears

5

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16 March 2020

publication date

24 April 2014

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16 March 2020

published in

Chemistry and Biology

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16 March 2020

volume

21

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issue

5

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16 March 2020

page(s)

689-699

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The enzymes of human diphosphoinositol polyphosphate metabolism

16 March 2020

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20 March 2017

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PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains

29 September 2017

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The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

29 September 2017

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Rapamycin passes the torch: a new generation of mTOR inhibitors

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Inositol polyphosphates, diphosphoinositol polyphosphates and phosphatidylinositol polyphosphate lipids: structure, synthesis, and development of probes for studying biological activity

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The biological significance of substrate inhibition: a mechanism with diverse functions

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Diphosphoinositol polyphosphates: metabolic messengers?

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Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells

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Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases

29 September 2017

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Docking and scoring in virtual screening for drug discovery: methods and applications

29 September 2017

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Regioselective opening of myo-inositol orthoesters: mechanism and synthetic utility.

29 September 2017

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Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain

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Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.

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Kinetic evidence of a noncatalytic substrate binding site that regulates activity in Legionella pneumophila L-serine dehydratase.

27 November 2018

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27 November 2018

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27 November 2018

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Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase fromSulfolobus solfataricus

27 November 2018

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Inositol diphosphate signaling regulates telomere length

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Regioselective hydrolysis of myo-inositol 1,3,5-orthobenzoate via a 1,2-bridged 2'-phenyl-1',3'-dioxolan-2'-ylium ion provides a rapid route to the anticancer agent Ins(1,3,4,5,6)P5

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24768307

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2014.03.009

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16 March 2020

1 reference

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16 March 2020

PubMed publication ID

24768307

2 references