Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response (Q28540195)

12

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Kitty McCaffrey

Kathleen McCaffrey

3

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Aleksandar David Kostić

Aleksandar D Kostic

4

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Andrew M Riley

Andrew M Riley

7

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Solomon Halbert Snyder

11

Solomon H Snyder

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Pradeep D Uchil

Pradeep D Uchil

9

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Stephen B Shears

Stephen B Shears

15

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Ramnik J Xavier

16

Ramnik J Xavier

0 references

Rongtuan Lin

14

Rongtuan Lin

0 references

Manoj N Krishnan

17

Manoj N Krishnan

0 references

Pradeep Bist

5

Pradeep Bist

0 references

Barry Potter

13

Barry V L Potter

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author name string

Niyas Kudukkil Pulloor

1

0 references

Sajith Nair

2

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Jeremy D Weaver

6

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Richa Tyagi

8

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John D York

Creative Commons CC0 License

10

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language of work or name

English

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publication date

February 2014

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published in

PLOS Pathogens

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volume

10

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issue

2

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page(s)

e1003981

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copyright license

start time

27 February 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.

29 September 2017

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New developments in the induction and antiviral effectors of type I interferon

29 September 2017

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29 September 2017

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Diphosphoinositol polyphosphates: what are the mechanisms?

29 September 2017

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Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro

29 September 2017

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Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

29 September 2017

1 reference

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High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors

29 September 2017

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RIG-I detects viral genomic RNA during negative-strand RNA virus infection

29 September 2017

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Recognition of viral nucleic acids in innate immunity

29 September 2017

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Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release

29 September 2017

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Inositol pyrophosphates: structure, enzymology and function

29 September 2017

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Enabling a systems biology approach to immunology: focus on innate immunity

29 September 2017

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Pathogen recognition in the innate immune response.

29 September 2017

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TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response

29 September 2017

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Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.

29 September 2017

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RNAither, an automated pipeline for the statistical analysis of high-throughput RNAi screens

29 September 2017

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Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis

29 September 2017

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Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937324

Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event

29 September 2017

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Identification of genes selectively regulated by IFNs in endothelial cells

29 September 2017

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Antiviral innate immunity pathways.

29 September 2017

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Inositol pyrophosphates: metabolism and signaling

29 September 2017

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Phosphorylation of proteins by inositol pyrophosphates

29 September 2017

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Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response

29 September 2017

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Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling

3 June 2018

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Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain

3 June 2018

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A microtiter plate assay for inorganic phosphate

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Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells

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The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response

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Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

24586175

1 reference