Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase (Q27683868)

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Nathalie Preiswerk

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Jessica D Schulz

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Peter Milovník

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Clemens Mayer

5

1 reference

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4 June 2020

Justin B Siegel

6

1 reference

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4 June 2020

David Baker

7

1 reference

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4 June 2020

Donald Hilvert

8

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

4 June 2020

language of work or name

English

0 references

publication date

3 June 2014

0 references

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

22

1 reference

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4 June 2020

page(s)

8013-8018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

Precision is essential for efficient catalysis in an evolved Kemp eliminase

4 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Evolution of a designed retro-aldolase leads to complete active site remodeling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Computational Design of Catalytic Dyads and Oxyanion Holes for Ester Hydrolysis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Protein Design by Directed Evolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Design of protein catalysts

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Computational enzyme design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Artificial metalloenzymes as catalysts in stereoselective Diels-Alder reactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

DNA-based asymmetric catalysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Chemistry and biology of biosynthetic Diels-Alder reactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

A small catalytic RNA motif with Diels-Alderase activity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050586

The putative Diels-Alderase macrophomate synthase is an efficient aldolase

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1401073111

DNA and RNA can be equally efficient catalysts for carbon-carbon bond formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1401073111

Experimental determination of the absolute enantioselectivity of an antibody-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1401073111

Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1401073111

RNA-catalysed carbon–carbon bond formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1401073111

Enantioselective Ribozyme Catalysis of a Bimolecular Cycloaddition Reaction This work was supported by the Deutsche Forschungsgemeinschaft (Grant no.: Ja 794/3-1) and the Bundesministerium für Bildung und Forschung (Grant no.: BEO 0311861). We thank

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24847076

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1401073111

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

ADS bibcode

2014PNAS..111.8013P

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

24847076

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847076%20AND%20SRC:MED&resulttype=core&format=json