Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 (Q27684443)

1

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Tianlong Zhang

2

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Shanshan Wang

3

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Zhou Gong

4

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Chun Tang

5

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Jiangye Chen

6

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Jianping Ding

GTPase networks in membrane traffic

7

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language of work or name

English

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publication date

23 June 2014

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published in

eLife

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volume

3

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cites work

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Structural basis for Rab GTPase activation by VPS9 domain exchange factors

20 March 2017

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20 March 2017

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Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

20 March 2017

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Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5

20 March 2017

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Structural basis of Rab5-Rabaptin5 interaction in endocytosis

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APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

20 March 2017

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Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3

20 March 2017

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Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex

20 March 2017

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Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex

20 March 2017

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Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition

20 March 2017

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A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release

20 March 2017

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Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain

20 March 2017

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EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

20 March 2017

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Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5

20 March 2017

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Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

20 March 2017

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Overview of the CCP4 suite and current developments

20 March 2017

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Version 1.2 of the Crystallography and NMR system

20 March 2017

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20 March 2017

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20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8.

20 March 2017

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Rab GTPases as coordinators of vesicle traffic

20 March 2017

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20 March 2017

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Processing of X-ray diffraction data collected in oscillation mode

22 April 2017

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Mechanisms of endocytosis

22 April 2017

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Super-resolution biomolecular crystallography with low-resolution data

7 April 2017

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A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function

7 April 2017

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7 April 2017

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Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster

22 April 2017

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Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons

29 September 2017

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PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5.

29 September 2017

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Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

29 September 2017

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Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination

29 September 2017

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Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.

29 September 2017

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Delayed onset of positive feedback activation of Rab5 by Rabex-5 and Rabaptin-5 in endocytosis

29 September 2017

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Regulation of endocytosis via the oxygen-sensing pathway

29 September 2017

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Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes

29 September 2017

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Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.

29 September 2017

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Membrane recruitment of effector proteins by Arf and Rab GTPases.

29 September 2017

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Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5.

29 September 2017

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Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia.

29 September 2017

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Phosphatidylinositol-3-OH kinases are Rab5 effectors.

29 September 2017

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Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes.

29 September 2017

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Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

29 September 2017

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Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

29 September 2017

1 reference

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Rabex-5 determines the neurite localization of its downstream Rab proteins in hippocampal neurons

2 June 2018

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Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell

2 June 2018

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Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins

2 June 2018

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PRIMUS: a Windows PC-based system for small-angle scattering data analysis

21 January 2018

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The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain

21 January 2018

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