Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain (Q27684872)

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Marc Adler

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Robert A Galemmo

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Simeon Bowers

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Anh P Truong

6

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Hu Pan

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Paul Beroza

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R Jeffrey Neitz

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Nanhua Yao

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May Lin

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George Tonn

12

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Heather Zhang

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Michael P Bova

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Zhao Ren

15

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Danny Tam

16

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Lany Ruslim

17

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Jeanne Baker

18

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Linnea Diep

19

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Kent Fitzgerald

20

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Jennifer Hoffman

21

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Ruth Motter

22

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Donald Fauss

23

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Pearl Tanaka

24

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Michael Dappen

25

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Jacek Jagodzinski

26

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Wayman Chan

27

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Andrei W Konradi

28

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Lee Latimer

29

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Yong L Zhu

30

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Hing L Sham

31

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John P Anderson

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Marcelle Bergeron

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Dean R Artis

Neuropathology of Lewy body disorders

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publication date

August 2013

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published in

ChemMedChem

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volume

8

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issue

8

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page(s)

1295-313

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

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Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

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Phosphorylation of synucleins by members of the Polo-like kinase family

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Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

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Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

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Polo-like kinases: a team in control of the division

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

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Targeting polo-like kinase 1 for cancer therapy.

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Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin

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The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus

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Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions

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Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

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Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity

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Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

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(3R,7aS)-3-(TRICHLOROMETHYL)TETRAHYDROPYRROLO[1,2-C]OXAZOL-1(3H)-ONE: AN AIR AND MOISTURE STABLE REAGENT FOR THE SYNTHESIS OF OPTICALLY ACTIVE α-BRANCHED PROLINES

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Kinases as targets for Parkinson's disease: from genetics to therapy

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Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors

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In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?

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Refinement of macromolecular structures by the maximum-likelihood method

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Microscopic analysis of polymerization dynamics with individual actin filaments

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inferred from DOI database lookup

7 January 2021

based on heuristic

Involvement of the Snk-SPAR pathway in glutamate-induced excitotoxicity in cultured hippocampal neurons

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/CMDC.201300166

0 references

Fatcat ID

release_yhfq7uc4zvdl5bgnvnjqkujnyq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yhfq7uc4zvdl5bgnvnjqkujnyq