Structural basis for the inhibition of bacterial multidrug exporters (Q27685149)

1

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Keisuke Sakurai

2

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Seiji Yamasaki

3

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Katsuhiko Hayashi

4

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Chikahiro Nagata

5

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Kazuki Hoshino

6

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Yoshikuni Onodera

7

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Akihito Yamaguchi

Multidrug resistance in Gram-negative bacteria.

9

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language of work or name

English

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publication date

1 August 2013

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published in

Nature

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volume

500

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issue

7460

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page(s)

102-6

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cites work

1 reference

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Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

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Practical applications and feasibility of efflux pump inhibitors in the clinic--a vision for applied use.

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Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria

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MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization

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Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa

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Contribution of the MexXY Multidrug Transporter to Aminoglycoside Resistance in Pseudomonas aeruginosa Clinical Isolates

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Involvement of the MexXY-OprM efflux system in emergence of cefepime resistance in clinical strains of Pseudomonas aeruginosa

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Crystal structure of bacterial multidrug efflux transporter AcrB

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Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

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AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex

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The assembled structure of a complete tripartite bacterial multidrug efflux pump

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Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance

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The role of multidrug efflux pumps in the antibiotic resistance of Pseudomonas aeruginosa and other gram-negative bacteria. Insights from the Society of Infectious Diseases Pharmacists

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Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

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Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa.

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Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels

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A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

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Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

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Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

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Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa

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The SWISS-MODEL Repository and associated resources

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Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB.

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Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.

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An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space

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Processing of X-ray diffraction data collected in oscillation mode

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The complete genome sequence of Escherichia coli K-12

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Role of the membrane fusion protein in the assembly of resistance-nodulation-cell division multidrug efflux pump in Pseudomonas aeruginosa.

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12 December 2020

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

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12 December 2020

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate

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12 December 2020

Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

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12 December 2020

Inhibition of efflux pumps as a novel approach to combat drug resistance in bacteria

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12 December 2020

Identifiers

DOI

10.1038/NATURE12300

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1045085615

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Fatcat ID

release_hucqe24fcnfyxhvldl4xwxfz5i

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hucqe24fcnfyxhvldl4xwxfz5i

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

23812586

1 reference

Consolidated OpenCitations Corpus – April 2017