A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study. (Q34077206)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16166543%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study (English)

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6 January 2020

2

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6 January 2020

author name string

Edward W Yu

series ordinal

1

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6 January 2020

Gerry McDermott

series ordinal

3

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6 January 2020

Hiroshi Nikaido

series ordinal

4

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6 January 2020

language of work or name

English

0 references

publication date

1 October 2005

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6 January 2020

published in

Journal of Bacteriology

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6 January 2020

volume

187

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6 January 2020

issue

19

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6 January 2020

page(s)

6804-6815

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

6 January 2020

cites work

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Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein

5 July 2018

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Structure of the periplasmic component of a bacterial drug efflux pump

5 July 2018

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Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa.

5 July 2018

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Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa

5 July 2018

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Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization

5 July 2018

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AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity

5 July 2018

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Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

5 July 2018

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Contributions of MexAB-OprM and an EmrE homolog to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes

5 July 2018

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Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria.

5 July 2018

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Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops

5 July 2018

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Crystal structure of bacterial multidrug efflux transporter AcrB

5 July 2018

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Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors

5 July 2018

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Amino acid residues essential for function of the MexF efflux pump protein of Pseudomonas aeruginosa

5 July 2018

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Mystery of multidrug transporters: the answer can be simple

5 July 2018

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Structural mechanisms of QacR induction and multidrug recognition

5 July 2018

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Analysis of a complete library of putative drug transporter genes in Escherichia coli

5 July 2018

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The kamikaze approach to membrane transport

5 July 2018

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

5 July 2018

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Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes

5 July 2018

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Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa

5 July 2018

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An approach to multi-copy search in molecular replacement

5 July 2018

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The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

5 July 2018

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Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli

5 July 2018

1 reference

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Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

5 July 2018

1 reference

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Complexes of porcine odorant binding protein with odorant molecules belonging to different chemical classes

5 July 2018

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Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin

5 July 2018

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5 July 2018

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Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli

5 July 2018

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5 July 2018

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Antibiotic resistance caused by gram-negative multidrug efflux pumps

5 July 2018

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A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

5 July 2018

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

5 July 2018

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Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli

5 July 2018

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Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

5 July 2018

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Molecular cloning and characterization of acrA and acrE genes of Escherichia coli

5 July 2018

1 reference

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Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli

5 July 2018

1 reference

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Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli

5 July 2018

1 reference

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Basic local alignment search tool

5 July 2018

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Purification and characterization of the membrane-associated components of the maltose transport system from Escherichia coli

5 July 2018

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Improved methods for building protein models in electron density maps and the location of errors in these models

5 July 2018

1 reference

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Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system.

5 July 2018

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AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex

28 October 2018

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Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport

28 October 2018

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An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space

28 October 2018

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On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

28 October 2018

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Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations.

28 October 2018

1 reference

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Processing of X-ray diffraction data collected in oscillation mode

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16166543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16166543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JB.187.19.6804-6815.2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16166543%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16166543%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PubMed publication ID

16166543

1 reference