Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase (Q27697984)

Thomas E Edwards

13

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Adrian S. Ray

Adrian S Ray

10

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Aesop Cho

6

Aesop Cho

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Joy Y Feng

5

Joy Feng

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Jason K Perry

2

Jason K Perry

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Ona Barauskas

4

Ona Barauskas

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Eisuke Murakami

3

Eisuke Murakami

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Todd R Appleby

1

Todd C Appleby

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author name string

David Fox

7

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Diana R Wetmore

8

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Mary E McGrath

9

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Michael J Sofia

Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

11

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language of work or name

English

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publication date

13 February 2015

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published in

Science

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volume

347

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issue

6223

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page(s)

771-5

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cites work

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

21 April 2017

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Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals

21 April 2017

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De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

21 April 2017

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Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis

21 April 2017

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Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405

21 April 2017

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A mechanism for initiating RNA-dependent RNA polymerization

21 April 2017

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Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase

21 April 2017

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 April 2017

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Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase

21 April 2017

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Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977

21 April 2017

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General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

21 April 2017

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Phasercrystallographic software

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Refinement of macromolecular structures by the maximum-likelihood method

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Coot: model-building tools for molecular graphics

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MolProbity: all-atom structure validation for macromolecular crystallography

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A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across Genotypes

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A mechanism for all polymerases

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Replication of hepatitis C virus

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OPTN/SRTR 2012 Annual Data Report: liver

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Treating hepatitis C: current standard of care and emerging direct-acting antiviral agents

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Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients

21 January 2018

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Nucleotide prodrugs for the treatment of HCV infection

21 January 2018

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Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C.

21 January 2018

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Review article: the efficacy and safety of sofosbuvir, a novel, oral nucleotide NS5B polymerase inhibitor, in the treatment of chronic hepatitis C virus infection

21 January 2018

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A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase

21 January 2018

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Conformational ensemble view of G protein-coupled receptors and the effect of mutations and ligand binding

21 January 2018

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Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance

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A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B.

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Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus

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Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus

21 January 2018

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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

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PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication

21 January 2018

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Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials.

21 January 2018

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Biochemical characterization of rhinovirus RNA-dependent RNA polymerase

21 January 2018

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Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development

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