A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors (Q27702580)

10

0 references

Gideon Davies

object named as

Gideon J Davies

9

0 references

author name string

Milan Bergeron-Brlek

1

0 references

Jake Goodwin-Tindall

2

0 references

Nevena Cekic

3

0 references

Wesley F Zandberg

5

0 references

Xiaoyang Shan

6

0 references

Vimal Varghese

7

0 references

Sherry Chan

8

0 references

Robert Britton

Angewandte Chemie International Edition

11

0 references

language of work or name

English

0 references

publication date

14 December 2015

0 references

published in

0 references

volume

54

0 references

issue

51

0 references

page(s)

15429-33

0 references

cites work

Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

The carbohydrate-active enzymes database (CAZy) in 2013

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Taking stock of telomere length at telome health

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

GlcNAcstatins are nanomolar inhibitors of human O -GlcNAcase inducing cellular hyper- O -GlcNAcylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Screening-based discovery of drug-likeO-GlcNAcase inhibitor scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Imino sugars and glycosyl hydrolases: historical context, current aspects, emerging trends

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

D-Fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Iminosugar-ferrocene conjugates as potential anticancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201507985