Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease (Q24656640)

8

object named as

Cheng-Xin Gong

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author name string

Fei Liu

1

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Jianhua Shi

2

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Hitoshi Tanimukai

3

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Jinhua Gu

4

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Jianlan Gu

5

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Khalid Iqbal

Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease

7

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language of work or name

English

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publication date

July 2009

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published in

Brain

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volume

132

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issue

Pt 7

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page(s)

1820-32

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cites work

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O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

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28 September 2017

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28 September 2017

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PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

28 September 2017

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

28 September 2017

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Oxidative damage in Alzheimer's disease: the metabolic dimension

28 September 2017

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Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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The metabolic topography of normal aging

28 September 2017

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Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: a longitudinal evaluation.

30 May 2018

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Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease.

30 May 2018

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Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

30 May 2018

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Effects of human aging on patterns of local cerebral glucose utilization determined by the [18F]fluorodeoxyglucose method.

30 May 2018

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Defective brain microtubule assembly in Alzheimer's disease

30 May 2018

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Cortical glutaminase, beta-glucuronidase and glucose utilization in Alzheimer's disease.

30 May 2018

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18Fluorodeoxyglucose positron emission tomography studies in presumed Alzheimer cases, including 13 serial scans.

30 May 2018

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Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.

30 May 2018

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Topography of cross-sectional and longitudinal glucose metabolic deficits in Alzheimer's disease. Pathophysiologic implications

30 May 2018

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Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

30 May 2018

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Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease.

28 November 2018

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Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702834

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

28 November 2018

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28 November 2018

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MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.

28 November 2018

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Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

28 November 2018

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Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702834

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein

28 November 2018

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Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

28 November 2018

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28 November 2018

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Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702834

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

28 November 2018

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Clinical deterioration in probable Alzheimer's disease correlates with progressive metabolic impairment of association areas.

28 November 2018

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Abnormalities of Energy Metabolism in Alzheimer's Disease Studied with PETa

28 November 2018

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Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers

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Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age

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Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase

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The selfish brain: competition for energy resources

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Identifiers

DOI

10.1093/BRAIN/AWP099

1 reference

4180522

4180522

1 reference

1 reference

1 reference