Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage (Q27703932)

7

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David W Taylor

object named as

David W Taylor

2

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Kaihong Zhou

5

object named as

Kaihong Zhou

0 references

Fuguo Jiang

1

object named as

Fuguo Jiang

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author name string

Janice S Chen

3

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Jack E Kornfeld

4

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Aubri J Thompson

STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

6

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language of work or name

English

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publication date

19 February 2016

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published in

Science

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volume

351

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issue

6275

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page(s)

867-71

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cites work

1 reference

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Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

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CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity

20 March 2017

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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

20 March 2017

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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase

20 March 2017

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Structure of Bam HI endonuclease bound to DNA: partial folding and unfolding on DNA binding

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Overview of the CCP4 suite and current developments

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

22 April 2017

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Molecular replacement with MOLREP

22 April 2017

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Maximum-likelihood density modification

22 April 2017

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Coot: model-building tools for molecular graphics

22 April 2017

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Phasercrystallographic software

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REFMAC5 for the refinement of macromolecular crystal structures

22 April 2017

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MolProbity: all-atom structure validation for macromolecular crystallography

22 April 2017

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Structural basis of RNA recognition and activation by innate immune receptor RIG-I

22 April 2017

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Accurate determination of local defocus and specimen tilt in electron microscopy

22 April 2017

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UCSF Chimera--a visualization system for exploratory research and analysis

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Electrostatics of nanosystems: application to microtubules and the ribosome

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

22 April 2017

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RELION: implementation of a Bayesian approach to cryo-EM structure determination

22 April 2017

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

22 April 2017

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RNA-guided genetic silencing systems in bacteria and archaea

7 April 2017

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Automated molecular microscopy: the new Leginon system

7 April 2017

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Appion: an integrated, database-driven pipeline to facilitate EM image processing

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Bsoft: image processing and molecular modeling for electron microscopy

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PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations

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Conformational control of DNA target cleavage by CRISPR-Cas9.

22 April 2017

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CRISPR-Cas immunity in prokaryotes

29 September 2017

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Crystal Structure of Staphylococcus aureus Cas9

29 September 2017

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Two distinct DNA binding modes guide dual roles of a CRISPR-Cas protein complex.

29 September 2017

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The structural biology of CRISPR-Cas systems

29 September 2017

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Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

29 September 2017

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Unravelling the structural and mechanistic basis of CRISPR-Cas systems

29 September 2017

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CRISPR-mediated adaptive immune systems in bacteria and archaea

29 September 2017

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Structural basis for CRISPR RNA-guided DNA recognition by Cascade

29 September 2017

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Short motif sequences determine the targets of the prokaryotic CRISPR defence system

29 September 2017

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Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection.

29 September 2017

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Substructure search procedures for macromolecular structures

21 January 2018

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SOLVE and RESOLVE: automated structure solution, density modification and model building

21 January 2018

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Alignment of cryo-EM movies of individual particles by optimization of image translations.

21 January 2018

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Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

21 January 2018

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21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAD8282

1 reference

ADS bibcode

2016Sci...351..867J

0 references

1 reference

1 reference

PubMed publication ID

26841432

1 reference