Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit (Q27728470)

GeneDB

cAMP-dependent protein kinase regulatory subunit, putative

11 September 2018

1 reference

25 September 2018

6

0 references

Travis Beddoe

4

0 references

Dene Littler

1

Dene R Littler

0 references

Brendan Crabb

5

Brendan S Crabb

0 references

Paul R Gilson

7

Paul R Gilson

0 references

Hayley E Bullen

2

Hayley E Bullen

0 references

author name string

Katherine L Harvey

Journal of Biological Chemistry

3

0 references

language of work or name

English

0 references

publication date

13 October 2016

0 references

published in

0 references

cites work

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Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite

20 March 2017

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Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit

20 March 2017

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PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

20 March 2017

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Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling

20 March 2017

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Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

20 March 2017

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Localization and quaternary structure of the PKA RI holoenzyme

20 March 2017

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Structure and Allostery of the PKA RII Tetrameric Holoenzyme

20 March 2017

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Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs

20 March 2017

1 reference

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PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease

20 March 2017

1 reference

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Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains

20 March 2017

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20 March 2017

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Features and development of Coot

20 March 2017

1 reference

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The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes

20 March 2017

1 reference

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Human malaria parasites in continuous culture

20 March 2017

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Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits

20 March 2017

1 reference

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cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission

20 March 2017

1 reference

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Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance

20 March 2017

1 reference

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Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of eighth biannual meeting (September 2015).

24 May 2017

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Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.

29 September 2017

1 reference

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Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparum schizonts develop into extracellular invasive merozoites

29 September 2017

1 reference

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Fitting two- and three-site binding models to isothermal titration calorimetric data

29 September 2017

1 reference

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Signaling through dynamic linkers as revealed by PKA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5207240

The algal past and parasite present of the apicoplast

29 September 2017

1 reference

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Plasmodium kinases as targets for new-generation antimalarials

29 September 2017

1 reference

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Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5207240

The role of cGMP signalling in regulating life cycle progression of Plasmodium

29 September 2017

1 reference

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The cAMP binding domain: an ancient signaling module

29 September 2017

1 reference

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The essential role of RI alpha in the maintenance of regulated PKA activity

29 September 2017

1 reference

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Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation

29 September 2017

1 reference

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Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

2 June 2018

1 reference

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The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.750174

Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.750174

The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes

21 January 2018

1 reference

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Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites.

21 January 2018

1 reference

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Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.750174

Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.750174

Measurement of the lactate dehydrogenase activity of Plasmodium falciparum as an assessment of parasitemia

21 January 2018

1 reference

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Purification and properties of rabbit skeletal muscle adenosine 3',5'-monophosphate-dependent protein kinases

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27738107