Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89 (Q27733608)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8846221%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

title

Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89 (English)

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20 October 2019

2

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20 October 2019

author name string

Weichsel A

series ordinal

1

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20 October 2019

publication date

1 December 1995

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Nature structural biology

20 October 2019

published in

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20 October 2019

volume

2

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20 October 2019

issue

12

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20 October 2019

page(s)

1095-1101

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Residues in chaperonin GroEL required for polypeptide binding and release

20 October 2019

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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

31 March 2020

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Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate

31 March 2020

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31 March 2020

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Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase

31 March 2020

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Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A

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Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89

31 March 2020

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Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases

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Structural basis for recognition of polyglutamyl folates by thymidylate synthase

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Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position

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Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding

31 March 2020

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

31 March 2020

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31 March 2020

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Stereochemically restrained refinement of macromolecular structures

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Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NSB1295-1095

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8846221%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

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