DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase (Q27739981)

2

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G D Jones

3

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R T Walker

4

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R J Roberts

5

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X Cheng

A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase

6

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language of work or name

English

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publication date

15 July 1997

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published in

Nucleic Acids Research

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volume

25

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issue

14

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page(s)

2773-83

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cites work

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A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

20 March 2017

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Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes

20 March 2017

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The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides

20 March 2017

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Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognition

20 March 2017

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Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine

20 March 2017

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HhaI methyltransferase flips its target base out of the DNA helix

20 March 2017

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The DNA (cytosine-5) methyltransferases

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The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing

20 March 2017

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

20 March 2017

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The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogs

20 March 2017

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Reaction of cytidine with semicarbazide in the presence of bisulfite. A rapid modification specific for single-stranded polynucleotide

20 March 2017

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Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity

20 March 2017

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Finding a basis for flipping bases.

29 September 2017

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Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides

29 September 2017

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Synthesis and antiviral activity of 2'-deoxy-4'-thio purine nucleosides

29 September 2017

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The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center

29 September 2017

1 reference

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The cysteine conserved among DNA cytosine methylases is required for methyl transfer, but not for specific DNA binding

29 September 2017

1 reference

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Synthesis and properties of oligodeoxynucleotides containing the analogue 2'-deoxy-4'-thiothymidine

29 September 2017

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29 September 2017

DNA methyltransferases

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M.HhaI binds tightly to substrates containing mismatches at the target base

29 September 2017

1 reference

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HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair

29 September 2017

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Cytosine methyltransferase from Escherichia coli in which active site cysteine is replaced with serine is partially active

29 September 2017

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29 September 2017

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Gametic imprinting in mammals

29 September 2017

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Predictive motifs derived from cytosine methyltransferases

29 September 2017

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Sequence-specific DNA binding by the MspI DNA methyltransferase

29 September 2017

1 reference

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5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase

29 September 2017

1 reference

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Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146812

Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146812

Purification, crystallization, and preliminary X-ray diffraction analysis of an M.HhaI-AdoMet complex.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146812

Recognition of structural perturbations in DNA by human DNA(cytosine-5)methyltransferase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146812

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

27 November 2018

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DNA methylation and cancer

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9207024

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular orbital (CNDO/2 and MINDO) calculations on protonated deoxyribonucleic acid bases. The effects of base protonation on intermolecular interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9207024

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kinetic and catalytic mechanism of HhaI methyltransferase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9207024