Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations (Q27748800)

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English	Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations	scientific article

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scholarly article

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Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations (English)

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crystal structure

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protein structure

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author name string

R Venkataramani

1

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K Swaminathan

2

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R Marmorstein

3

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language of work or name

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publication date

January 1998

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Nature structural biology

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5

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1

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74-81

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

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Structure of the cyclin-dependent kinase inhibitor p19Ink4d

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Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

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Identification of CDK4 sequences involved in cyclin D1 and p16 binding

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Principles of CDK regulation

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Crystal structure of cyclin-dependent kinase 2

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A graphics model building and refinement system for macromolecules

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Cdk inhibitors: on the threshold of checkpoints and development

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The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

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Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions

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CDKN2A (p16INK4A) somatic and germline mutations

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The p19INK4D cyclin dependent kinase inhibitor gene is altered in osteosarcoma

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Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines

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Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism

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NMR structural characterization of the CDK inhibitor p19INK4d.

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Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures.

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Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein

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The retinoblastoma protein and cell cycle control

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Mutations associated with familial melanoma impair p16INK4 function.

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A cell cycle regulator potentially involved in genesis of many tumor types

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

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Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins

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The ANK repeat: a ubiquitous motif involved in macromolecular recognition

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Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?

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Nuclear magnetic resonance assignment and secondary structure of an ankyrin-like repeat-bearing protein: myotrophin

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

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Crystallographic R factor refinement by molecular dynamics

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10.1038/NSB0198-74

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