Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential (Q27748804)

1

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R A Engh

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A Girod

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V Kinzel

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R Huber

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D Bossemeyer

A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

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publication date

15 December 1997

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published in

Structure

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volume

5

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issue

12

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page(s)

1627-37

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cites work

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7 January 2021

28 Use and specificity of staurosporine, UCN-O1, and calphostin C as protein kinase inhibitors

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7 January 2021

Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases

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Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

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Characterization of specific binding sites for [3H]-staurosporine on various protein kinases

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Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-I receptor.

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7 January 2021

Staurosporine causes epidermal growth factor to induce differentiation in PC12 cells via receptor up-regulation

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Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C.

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Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.

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Programmed cell death and the control of cell survival: lessons from the nervous system

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A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity

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7 January 2021

Staurosporine: An Effective Inhibitor for Ca2+/Calmodulin-Dependent Protein Kinase II

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7 January 2021

Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2

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7 January 2021

Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity

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7 January 2021

Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity

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7 January 2021

High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design

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7 January 2021

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

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Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

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Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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Modelling study of protein kinase inhibitors: binding mode of staurosporine and origin of the selectivity of CGP 52411

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Inhibition mechanisms of staurosporine and H7 to cAMP-dependent protein kinase through docking study

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7 January 2021

Cloning of the C alpha catalytic subunit of the bovine cAMP-dependent protein kinase

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7 January 2021

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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7 January 2021

Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine

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Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

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Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation

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A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility

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Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations

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Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

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2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent

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Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy

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Adenosine cyclic 3',5'-monophosphate-dependent protein kinase: Interaction of the catalytic subunit and holoenzyme with lin-benzoadenine nucleotides

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Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

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The glycine-rich sequence of protein kinases: a multifunctional element

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Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition

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Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states.

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In vivo activation of recombinant cAPK catalytic subunit active site mutants by coexpression of the wild-type enzyme, evidence for intermolecular cotranslational phosphorylation

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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Accurate bond and angle parameters for X-ray protein structure refinement

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X-Ray crystal structure of staurosporine: a new alkaloid from a Streptomyces strain

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Absolute Configuration of Staurosporine By X-Ray Analysis

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10.1016/S0969-2126(97)00310-9

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

3071840

3071840

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference