UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy (Q27851574)

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English	UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy	scientific article

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scholarly article

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PubMed publication ID

13 November 2016

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy (English)

2 references

PubMed publication ID

13 November 2016

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

0 references

colorectal cancer

1 reference

based on heuristic

inferred from title

0 references

colorectal carcinoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Eva Martínez-Balibrea

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Anna Martínez-Cardús

4

1 reference

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7 February 2020

15

1 reference

Europe PubMed Central

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7 February 2020

author name string

E Martinez-Balibrea

1

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7 February 2020

A Abad

2

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7 February 2020

A Ginés

5

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7 February 2020

M Valladares

6

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7 February 2020

M Navarro

7

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7 February 2020

E Aranda

8

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7 February 2020

E Marcuello

9

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7 February 2020

M Benavides

10

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7 February 2020

B Massutí

11

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7 February 2020

A Carrato

12

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7 February 2020

L Layos

13

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7 February 2020

J L Manzano

14

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7 February 2020

language of work or name

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publication date

13 July 2010

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7 February 2020

British Journal of Cancer

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

103

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7 February 2020

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

581-589

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics

1 reference

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20 March 2017

UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer

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20 March 2017

Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy

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20 March 2017

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20 March 2017

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

20 March 2017

A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

20 March 2017

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

1 reference

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22 April 2017

Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Innovations in chemotherapy for metastatic colorectal cancer: an update of recent clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

UGT1A1*28 polymorphism predicts irinotecan-induced severe toxicities without affecting treatment outcome and survival in patients with metastatic colorectal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Randomized study of weekly irinotecan plus high-dose 5-fluorouracil (FUIRI) versus biweekly irinotecan plus 5-fluorouracil/leucovorin (FOLFIRI) as first-line chemotherapy for patients with metastatic colorectal cancer: a Spanish Cooperative Group fo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial

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https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene

1 reference

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21 January 2018

Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Camptothecin analogues: studies from the Johns Hopkins Oncology Center.

1 reference

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21 January 2018

SNPStats: a web tool for the analysis of association studies.

1 reference

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21 January 2018

UGT1A1 Polymorphism Can Predict Hematologic Toxicity in Patients Treated with Irinotecan

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

27 November 2018

Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer

1 reference

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27 November 2018

Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression

1 reference

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27 November 2018

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6605776

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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PMC publication ID

2 references

PubMed publication ID

13 November 2016

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

2 references

PubMed publication ID

13 November 2016

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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