Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. (Q27851801)

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Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial

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English	Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.	scientific article	Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial

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scholarly article

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13 November 2016

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1 February 2020

Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial (English)

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1 February 2020

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phase I clinical trial

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brain metastasis

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Georgina V. Long

2

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1 February 2020

Michael P. Brown

6

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1 February 2020

Richard F. Kefford

17

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1 February 2020

Razelle Kurzrock

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Razelle Kurzrock

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1 February 2020

Michael Millward

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Michael Millward

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1 February 2020

Peter F Lebowitz

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Peter Lebowitz

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1 February 2020

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Omid Hamid

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1 February 2020

Gerald Falchook

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Gerald S Falchook

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1 February 2020

Daniele Ouellet

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Daniele Ouellet

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1 February 2020

Jeffrey R Infante

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Jeffrey R Infante

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1 February 2020

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Anna C Pavlick

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1 February 2020

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Kevin B Kim

4

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1 February 2020

Tobias H Arkenau

5

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1 February 2020

Steven J O'Day

11

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1 February 2020

Samuel C Blackman

12

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1 February 2020

C Martin Curtis

13

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1 February 2020

Bo Ma

15

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1 May 2012

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1 February 2020

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1 February 2020

379

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1 February 2020

1893-1901

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1 February 2020

9829

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1 February 2020

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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20 March 2017

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

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20 March 2017

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

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20 March 2017

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

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20 March 2017

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

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20 March 2017

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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20 March 2017

Mutations of the BRAF gene in human cancer

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20 March 2017

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

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20 March 2017

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

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20 March 2017

BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study

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20 March 2017

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

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7 April 2017

Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

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7 April 2017

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

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7 April 2017

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

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7 April 2017

Final version of 2009 AJCC melanoma staging and classification

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7 April 2017

RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models

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Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.

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27 November 2018

Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.

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27 November 2018

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

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7 January 2021

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Prognostic factors for survival in melanoma patients with brain metastases

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https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960398-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960398-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960398-5

7 January 2021

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Accelerated titration designs for phase I clinical trials in oncology

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https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960398-5

7 January 2021

based on heuristic

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Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960398-5

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Identifiers

10.1016/S0140-6736(12)60398-5

2 references

Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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1 February 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22608338%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22608338%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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