Crizotinib in ROS1-rearranged non-small-cell lung cancer. (Q27853075)

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20 February 2020

title

Crizotinib in ROS1-rearranged non-small-cell lung cancer (English)

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20 February 2020

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Zongli Zheng

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Yung-Jue Bang

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A John Iafrate

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Keith D Wilner

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D Ross Camidge

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Benjamin J Solomon

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Alice T Shaw

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James G Christensen

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Robert C Doebele

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20 February 2020

Marileila Varella-Garcia

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object named as

Marileila Varella-Garcia

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Gregory J Riely

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20 February 2020

author name string

Sai-Hong I Ou

2

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Geoffrey I Shapiro

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Long Phi Le

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Weiwei Tan

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Patricia Stephenson

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S Martin Shreeve

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Lesley M Tye

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Jeffrey W Clark

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Ravi Salgia

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20 February 2020

language of work or name

English

0 references

publication date

27 September 2014

1 reference

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The New England Journal of Medicine

20 February 2020

published in

1 reference

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20 February 2020

volume

371

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issue

21

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20 February 2020

page(s)

1963-1971

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Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study.

20 February 2020

cites work

1 reference

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20 March 2017

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Ceritinib in ALK-rearranged non-small-cell lung cancer

20 March 2017

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Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib

20 March 2017

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Acquired Resistance to Crizotinib from a Mutation in CD74 – ROS1

20 March 2017

1 reference

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Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.

20 March 2017

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ROS1 rearrangements define a unique molecular class of lung cancers

20 March 2017

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

20 March 2017

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Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

20 March 2017

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EPLIN, epithelial protein lost in neoplasm

20 March 2017

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Characterization of an activated human ros gene

20 March 2017

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Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule

20 March 2017

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Moesin: a member of the protein 4.1-talin-ezrin family of proteins

20 March 2017

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

20 March 2017

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Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)

20 March 2017

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

20 March 2017

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Toxicity and response criteria of the Eastern Cooperative Oncology Group

7 April 2017

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Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer

7 April 2017

1 reference

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Novel targets in non-small cell lung cancer: ROS1 and RET fusions

29 September 2017

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Molecular pathways: ROS1 fusion proteins in cancer

29 September 2017

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Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

29 September 2017

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29 September 2017

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Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer.

29 September 2017

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Chromosome 3 anomalies investigated by genome wide SNP analysis of benign, low malignant potential and low grade ovarian serous tumours

29 September 2017

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Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma

29 September 2017

1 reference

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The multifaceted roles of the receptor tyrosine kinase ROS in development and cancer

29 September 2017

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29 September 2017

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Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,

29 September 2017

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2 June 2018

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27 November 2018

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27 November 2018

Identifiers

DOI

10.1056/NEJMOA1406766

2 references

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20 February 2020

1 reference

2 references

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20 February 2020

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