Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor (Q27853093)

13

Mari Mino-Kenudson

0 references

Avinash Ramu

Avinash Ramu

9

0 references

Benjamin J Ainscough

Benjamin J Ainscough

8

0 references

Pau Castel

Pau Castel

2

0 references

Ronak H Shah

Ronak H Shah

11

0 references

Malachi Griffith

Malachi Griffith

3

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Obi Griffith

4

Obi L Griffith

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author name string

Dejan Juric

1

0 references

Helen H Won

5

0 references

Haley Ellis

6

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Saya H Ebbesen

7

0 references

Gopa Iyer

10

0 references

Tiffany Huynh

12

0 references

Dennis Sgroi

14

0 references

Steven Isakoff

15

0 references

Ashraf Thabet

16

0 references

Leila Elamine

17

0 references

David B Solit

18

0 references

Scott W Lowe

19

0 references

Cornelia Quadt

20

0 references

Malte Peters

21

0 references

Adnan Derti

22

0 references

Robert Schegel

23

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Alan Huang

24

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Michael F Berger

26

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José Baselga

27

0 references

Maurizio Scaltriti

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

28

0 references

language of work or name

English

0 references

publication date

12 February 2015

0 references

published in

Nature

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volume

518

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issue

7538

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page(s)

240-4

0 references

cites work

1 reference

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

20 March 2017

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20 March 2017

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20 March 2017

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

20 March 2017

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A framework for variation discovery and genotyping using next-generation DNA sequencing data

20 March 2017

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

7 April 2017

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

7 April 2017

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7 April 2017

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29 September 2017

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Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

29 September 2017

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High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing

29 September 2017

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Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer

29 September 2017

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Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice

29 September 2017

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Transforming properties of 8p11-12 amplified genes in human breast cancer

29 September 2017

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Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors

29 September 2017

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Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

29 September 2017

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Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

29 September 2017

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Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

29 September 2017

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Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain

29 September 2017

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High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1.

2 June 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNATURE13948

21 January 2018

Identifiers

DOI

10.1038/NATURE13948

1 reference

Dimensions Publication ID

674769

1040238174

0 references

674769

1 reference

1 reference

1 reference