The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism (Q29547302)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847462%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

review article

1 reference

title

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism (English)

2 references

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23 April 2017

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27 December 2019

3

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27 December 2019

author name string

Jeffrey A Engelman

series ordinal

1

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27 December 2019

Ji Luo

series ordinal

2

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27 December 2019

language of work or name

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23 April 2017

publication date

1 August 2006

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27 December 2019

published in

Nature Reviews Genetics

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23 April 2017

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27 December 2019

volume

7

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23 April 2017

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27 December 2019

page(s)

606-619

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27 December 2019

issue

8

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23 April 2017

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The phosphoinositide 3-kinase pathway

27 December 2019

cites work

1 reference

p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

25 April 2017

1 reference

The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking

25 April 2017

1 reference

Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy

25 April 2017

1 reference

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

25 April 2017

1 reference

Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment

25 April 2017

1 reference

A C. elegans mutant that lives twice as long as wild type

25 April 2017

1 reference

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

25 April 2017

1 reference

Genetic pathways that regulate ageing in model organisms

25 April 2017

1 reference

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

25 April 2017

1 reference

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

25 April 2017

1 reference

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

25 April 2017

1 reference

Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

25 April 2017

1 reference

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

25 April 2017

1 reference

Insulin signalling and the regulation of glucose and lipid metabolism

25 April 2017

1 reference

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action

25 April 2017

1 reference

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

25 April 2017

1 reference

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

25 April 2017

1 reference

Physiological functions of protein kinase B/Akt

25 April 2017

2 references

25 April 2017

inferred from DOI database lookup

7 January 2021

based on heuristic

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

25 April 2017

1 reference

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

25 April 2017

1 reference

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

25 April 2017

1 reference

The biology and clinical relevance of the PTEN tumor suppressor pathway

25 April 2017

1 reference

Pten dose dictates cancer progression in the prostate

25 April 2017

1 reference

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

25 April 2017

1 reference

High frequency of mutations of the PIK3CA gene in human cancers

25 April 2017

1 reference

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

25 April 2017

1 reference

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

25 April 2017

1 reference

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

25 April 2017

1 reference

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

25 April 2017

1 reference

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

25 April 2017

1 reference

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

25 April 2017

1 reference

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

25 April 2017

1 reference

SH2 domains recognize specific phosphopeptide sequences

25 April 2017

1 reference

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

25 April 2017

1 reference

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

25 April 2017

1 reference

PDK1, the master regulator of AGC kinase signal transduction

25 April 2017

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

25 April 2017

1 reference

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

25 April 2017

1 reference

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

25 April 2017

1 reference

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

25 April 2017

1 reference

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

25 April 2017

1 reference

14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation

25 April 2017

1 reference

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

25 April 2017

1 reference

Somatic mutation and gain of copy number of PIK3CA in human breast cancer

25 April 2017

1 reference

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

25 April 2017

1 reference

Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas

25 April 2017

1 reference

Mutations of PIK3CA in gastric adenocarcinoma

25 April 2017

1 reference

PIK3CA as an oncogene in cervical cancer

25 April 2017

1 reference

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

25 April 2017

1 reference

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

25 April 2017

1 reference

Akt regulates growth by directly phosphorylating Tsc2

25 April 2017

1 reference

Critical nodes in signalling pathways: insights into insulin action

25 April 2017

1 reference

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

25 April 2017

1 reference

A central role for JNK in obesity and insulin resistance

25 April 2017

1 reference

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

25 April 2017

1 reference

25 April 2017

Phosphoinositide kinases

1 reference

25 April 2017

The renaissance of GSK3

1 reference

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

25 April 2017

1 reference

Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy

31 March 2020

1 reference

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

31 March 2020

1 reference

Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

31 March 2020

1 reference

Phosphoinositide signaling and the regulation of membrane trafficking in yeast

31 March 2020

1 reference

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

31 March 2020

1 reference

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

31 March 2020

1 reference

Chemotaxis: signalling the way forward

31 March 2020

1 reference

A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole

31 March 2020

1 reference

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole

31 March 2020

1 reference

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells

31 March 2020

1 reference

A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast

31 March 2020

1 reference

Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway

31 March 2020

1 reference

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control

31 March 2020

1 reference

Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila.

31 March 2020

1 reference

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

31 March 2020

1 reference

Analysis of insulin signalling by RNAi-based gene silencing

31 March 2020

1 reference

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

31 March 2020

1 reference

Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue

31 March 2020

1 reference

Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.

31 March 2020

1 reference

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ

31 March 2020

1 reference

Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle

31 March 2020

1 reference

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess

31 March 2020

1 reference

Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling

31 March 2020

1 reference

Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle

31 March 2020

1 reference

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

31 March 2020

1 reference

The role of the insulin-like growth factor-I receptor in cancer

31 March 2020

1 reference

The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway

31 March 2020

1 reference

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

31 March 2020

1 reference

Akt/protein kinase B promotes organ growth in transgenic mice

31 March 2020

1 reference

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

31 March 2020

1 reference

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.

31 March 2020

1 reference

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

31 March 2020

1 reference

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

31 March 2020

1 reference

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

31 March 2020

1 reference

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol

31 March 2020

1 reference

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

31 March 2020

1 reference

Human cancer, PTEN and the PI-3 kinase pathway

31 March 2020

1 reference

Impaired Fas response and autoimmunity in Pten+/- mice

31 March 2020

1 reference

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

31 March 2020

1 reference

Oncogenic PI3K deregulates transcription and translation

31 March 2020

1 reference

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

31 March 2020

1 reference

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

31 March 2020

1 reference

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

31 March 2020

1 reference

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

31 March 2020

1 reference

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

31 March 2020

1 reference

Colorectal cancer: mutations in a signalling pathway.

31 March 2020

1 reference

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

31 March 2020

1 reference

Restraining PI3K: mTOR signalling goes back to the membrane.

31 March 2020

1 reference

PKC-theta knockout mice are protected from fat-induced insulin resistance

31 March 2020

1 reference

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

31 March 2020

1 reference

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease

31 March 2020

1 reference

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

31 March 2020

1 reference

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

31 March 2020

1 reference

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

31 March 2020

1 reference

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

31 March 2020

1 reference

FoxO proteins in insulin action and metabolism

31 March 2020

1 reference

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

31 March 2020

1 reference

PI3-kinase and TOR: PIKTORing cell growth

31 March 2020

1 reference

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

31 March 2020

1 reference

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

31 March 2020

1 reference

Growing roles for the mTOR pathway

31 March 2020

1 reference

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

31 March 2020

1 reference

Common mechanism for oncogenic activation of MLL by forkhead family proteins

31 March 2020

1 reference

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

31 March 2020

1 reference

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

31 March 2020

1 reference

The PIK3CA gene is mutated with high frequency in human breast cancers.

31 March 2020

1 reference

Mutation of the PIK3CA gene in ovarian and breast cancer

31 March 2020

1 reference

The prevalence of PIK3CA mutations in gastric and colon cancer.

31 March 2020

1 reference

PIK3CA mutations in glioblastoma multiforme.

31 March 2020

1 reference

Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma

31 March 2020

1 reference

Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma.

31 March 2020

1 reference

Uncommon Mutation, but Common Amplifications, of thePIK3CAGene in Thyroid Tumors

31 March 2020

1 reference

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

31 March 2020

1 reference

PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.

31 March 2020

1 reference

PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.

31 March 2020

1 reference

Analysis of PTEN and the 10q23 region in primary prostate carcinomas

31 March 2020

1 reference

PTEN/MMAC1/TEP1 involvement in primary prostate cancers.

31 March 2020

1 reference

Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN

31 March 2020

1 reference

Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.

31 March 2020

1 reference

Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomas

31 March 2020

1 reference

PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines

31 March 2020

1 reference

Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies

31 March 2020

1 reference

Identification of PTEN mutations in metastatic melanoma specimens

31 March 2020

1 reference

Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas

31 March 2020

1 reference

PTEN mutations in gliomas and glioneuronal tumors.

31 March 2020

1 reference

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

31 March 2020

1 reference

Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16847462

31 March 2020

Identifiers

3 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017

118860

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847462%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

27 December 2019

1018626271

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118860

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16847462

3 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017

118860

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847462%20AND%20SRC:MED&resulttype=core&format=json