The GTPase superfamily: conserved structure and molecular mechanism (Q27860524)

Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins

Europe PubMed Central

title

The GTPase superfamily: conserved structure and molecular mechanism (English)

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author name string

H R Bourne

series ordinal

1

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D A Sanders

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2

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F McCormick

series ordinal

3

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language of work or name

English

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publication date

10 January 1991

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published in

Nature

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volume

349

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page(s)

117-27

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issue

6305

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cites work

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Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21.

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Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

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Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain

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Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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The GTPase superfamily: a conserved switch for diverse cell functions

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Conformational changes involved in the activation of ras p21: implications for related proteins

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G proteins: a family of signal transducers

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Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae

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The role of guanosine 5′-triphosphate in polypeptide chain elongation

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G proteins: transducers of receptor-generated signals

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Roles of G protein subunits in transmembrane signalling.

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G proteins control diverse pathways of transmembrane signaling.

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Signal sorting and amplification through G protein-coupled receptors

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A role for Ni in the hormonal stimulation of adenylate cyclase

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Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

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A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins

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Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

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Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

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Hydrolysis of GTP by p21NRAS, the NRAS protooncogene product, is accompanied by a conformational change in the wild-type protein: use of a single fluorescent probe at the catalytic site

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Biochemical and crystallographic characterization of a complex of c-Ha-ras p21 and caged GTP with flash photolysis

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A mutation that prevents GTP-dependent activation of the alpha chain of Gs.

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Homologies between signal transducing G proteins and ras gene products

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GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

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Biological and biochemical properties of human rasH genes mutated at codon 61.

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Hydrolysis of GTP by the alpha-chain of Gs and other GTP binding proteins

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Two G protein oncogenes in human endocrine tumors

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Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

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Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase

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Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

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ras GTPase activating protein: signal transmitter and signal terminator

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Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant

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ras and GAP--who's controlling whom?

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H-ras mutants lacking the epitope for the neutralizing monoclonal antibody Y13-259 show decreased biological activity and are deficient in GTPase-activating protein interaction

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Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.

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Chimeric proteins define variable and essential regions of Ha-ras-encoded protein

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The nucleotide sequence of theEscherichta coli fusgene, coding for elongation factor G

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Characterization of the str operon genes from Spirulina platensis and their evolutionary relationship to those of other prokaryotes.

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Genes for the ribosomal proteins S12 and S7 and elongation factors EF-G and EF-Tu of the cyanobacterium, Anacystis nidulans: Structural homology between 16S rRNA and S7 mRNA

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Molecular cloning and sequence determination of the tuf gene coding for the elongation factor Tu of Thermus thermophilus HB8.

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Organization and codon usage of the streptomycin operon in Micrococcus luteus, a bacterium with a high genomic G + C content

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Nucleotide sequence of aEuglena gracilischloroplast genome region coding for the elongation factor Tu; evidence for a spliced mRNA

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Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae

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The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites

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Structure and expression of elongation factor 1 alpha in tomato.

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A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain

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7 January 2021

Amino acid sequence of mammalian elongation factor 2 deduced from the cDNA sequence: homology with GTP-binding proteins

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7 January 2021

Sequence of the initiation factor IF2 gene: unusual protein features and homologies with elongation factors.

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7 January 2021

Identification, cloning and sequence of the Streptococcus faecium infB (translational initiation factor IF2) gene

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7 January 2021

The Bacillus subtilis spo0B stage 0 sporulation operon encodes an essential GTP-binding protein

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7 January 2021

Comparative biochemical properties of normal and activated human ras p21 protein

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7 January 2021

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

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7 January 2021

Structure and activation of the human N-ras gene

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7 January 2021

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.

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7 January 2021

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

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7 January 2021

Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian ras protein.

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7 January 2021

Characterization and developmental expression of a Drosophila ras oncogene

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7 January 2021

Expression of an activated ras gene causes developmental abnormalities in transgenic Drosophila melanogaster.

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7 January 2021

The Drosophila ras oncogenes: structure and nucleotide sequence.

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7 January 2021

Nucleotide sequence of human rho cDNA clone 12.

1 reference

7 January 2021

Coding sequence of human rho cDNAs clone 6 and clone 9

1 reference

7 January 2021

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae

1 reference

7 January 2021

Cloning of ara, a putative Arabidopsis thaliana gene homologous to the ras-related gene family

1 reference

7 January 2021

A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product

1 reference

7 January 2021

Genes encoding novel GTP-binding proteins in Dictyostelium

1 reference

7 January 2021

A ras-like protein is required for a post-Golgi event in yeast secretion

1 reference

7 January 2021

A new member of the ras gene superfamily identified in a rat liver cell line

1 reference

7 January 2021

Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin

1 reference

7 January 2021

Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins

1 reference

7 January 2021

Diverse biological functions of small GTP-binding proteins in yeast

1 reference

7 January 2021

A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus.

1 reference

7 January 2021

Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase

1 reference

7 January 2021

Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence

1 reference

7 January 2021

Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin

1 reference

7 January 2021

Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit

1 reference

7 January 2021

Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins

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7 January 2021

The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway.

1 reference

7 January 2021

Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions

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7 January 2021

Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium

1 reference

7 January 2021

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

1 reference

7 January 2021

Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains

1 reference

7 January 2021

Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth

1 reference

7 January 2021

The nucleotide sequence of an Escherichia coli operon containing genes for the tRNA(m1G)methyltransferase, the ribosomal proteins S16 and L19 and a 21-K polypeptide.

1 reference

7 January 2021

A new cell division operon in Escherichia coli.

1 reference

7 January 2021

Topology of signal recognition particle receptor in endoplasmic reticulum membrane.

1 reference

7 January 2021

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.

1 reference

7 January 2021

Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25.

1 reference

7 January 2021

Identification of receptor contact site involved in receptor-G protein coupling

1 reference

7 January 2021

Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit

1 reference

7 January 2021

Sequence analysis of bovine retinal S-antigen. Relationships with alpha-transducin and G-proteins.

1 reference

7 January 2021

Studies on the polypeptide elongation factors form E. coli. VI. Characterization of sulfhydryl groups in EF-Tu and EF-Ts

1 reference

7 January 2021

A new RAS mutation that suppresses the CDC25 gene requirement for growth of Saccharomyces cerevisiae

1 reference

7 January 2021

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects

1 reference

7 January 2021

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

1 reference

7 January 2021

Mutational analysis of a ras catalytic domain

1 reference

7 January 2021

Cloning of bovine GAP and its interaction with oncogenic ras p21.

1 reference

7 January 2021

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product.

1 reference

7 January 2021

Conformation change of effector-region residues in antiparallel β-sheet of human c-Ha-ras protein on GDP→GTPγS exchange: A two-dimensional NMR study

1 reference

7 January 2021

Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product

1 reference

7 January 2021

Antibodies to synthetic peptide from the residue 33 to 42 domain of c-Ha-ras p21 block reconstitution of the protein with different effectors

1 reference

7 January 2021

Ras interaction with the GTPase-activating protein (GAP).

1 reference

7 January 2021