Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo (Q27861933)

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24 February 2020

title

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo (English)

1 reference

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24 February 2020

main subject

malaria

0 references

threonine--tRNA ligase

1 reference

11 September 2018

Eva Maria Novoa Pardo

1

1 reference

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24 February 2020

Eva Maria Novoa Pardo

2

1 reference

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24 February 2020

Patricia Marín-García

7

1 reference

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24 February 2020

José M. Bautista

9

1 reference

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24 February 2020

Miriam Royo

13

1 reference

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24 February 2020

Alfred Cortés

14

1 reference

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24 February 2020

author name string

Noelia Camacho

3

1 reference

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24 February 2020

Anna Tor

4

1 reference

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24 February 2020

Barrie Wilkinson

5

1 reference

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24 February 2020

Steven Moss

6

1 reference

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24 February 2020

Isabel G Azcárate

8

1 reference

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24 February 2020

Adam C Mirando

10

1 reference

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24 February 2020

Christopher S Francklyn

11

1 reference

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24 February 2020

Sònia Varon

12

1 reference

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24 February 2020

Lluís Ribas de Pouplana

15

1 reference

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24 February 2020

language of work or name

English

0 references

publication date

8 December 2014

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

24 February 2020

published in

1 reference

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24 February 2020

volume

111

1 reference

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24 February 2020

issue

51

1 reference

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24 February 2020

page(s)

E5508-17

1 reference

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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

24 February 2020

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20 March 2017

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Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment

20 March 2017

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20 March 2017

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20 March 2017

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Genome sequence of the human malaria parasite Plasmodium falciparum

20 March 2017

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Protein secondary structure prediction based on position-specific scoring matrices

20 March 2017

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20 March 2017

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Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum

20 March 2017

1 reference

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The apicoplast as an antimalarial drug target

20 March 2017

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Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

20 March 2017

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

20 March 2017

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Chemical genetics of Plasmodium falciparum

20 March 2017

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7 April 2017

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Multiple protein sequence alignment from tertiary structure comparison: assignment of global and residue confidence levels

7 April 2017

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Validation of isoleucine utilization targets in Plasmodium falciparum

7 April 2017

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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

24 May 2017

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Why do malaria parasites increase host erythrocyte permeability?

24 May 2017

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Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites

29 September 2017

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Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin

29 September 2017

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Antimalarial drug resistance and early drug discovery

29 September 2017

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Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms

29 September 2017

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Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

29 September 2017

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29 September 2017

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Outwitting evolution: fighting drug-resistant TB, malaria, and HIV.

29 September 2017

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Boron-based drugs as antiprotozoals

29 September 2017

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Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum

29 September 2017

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A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro

29 September 2017

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29 September 2017

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Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility

29 September 2017

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Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies

29 September 2017

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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

29 September 2017

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29 September 2017

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Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases

29 September 2017

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Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast

29 September 2017

1 reference

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AN-2690, a novel antifungal for the topical treatment of onychomycosis.

29 September 2017

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Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain

29 September 2017

1 reference

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Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

29 September 2017

1 reference

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents

29 September 2017

1 reference

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Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria

29 September 2017

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Antimalarial drug discovery: efficacy models for compound screening

29 September 2017

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Heme binding contributes to antimalarial activity of bis-quaternary ammoniums

29 September 2017

1 reference

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Biosynthetic pathways of plastid-derived organelles as potential drug targets against parasitic apicomplexa

29 September 2017

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Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics

29 September 2017

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Comparative protein modeling by satisfaction of spatial restraints

29 September 2017

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Mupirocin: a topical antibiotic with a unique structure and mechanism of action

29 September 2017

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Mupirocin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

29 September 2017

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Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum.

29 September 2017

1 reference

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Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

2 June 2018

1 reference

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Anti-Candida activity of cispentacin: the active transport by amino acid permeases and possible mechanisms of action

2 June 2018

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Chinese hamster ovary cells resistant to borrelidin overproduce threonyl-tRNA synthetase.

2 June 2018

1 reference

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Effect of the antibiotic Borrelidin on the regulation of threonine biosynthetic enzymes in E.coli

2 June 2018

1 reference

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Evaluation of Clindamycin in Combination with Quinine against Multidrug-Resistant Strains of Plasmodium Falciparum

2 June 2018

1 reference

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A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405994111

The effects of anti-bacterials on the malaria parasite Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405994111

Stereoselective total synthesis of (-)-borrelidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405994111

Discovering and developing new medicines for malaria control and elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405994111

Effect of dietary p-aminobenzoic acid on murine Plasmodium yoelii infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405994111

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405994111

Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280603

Diamidine compounds: selective uptake and targeting in Plasmodium falciparum.

27 November 2018

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Aminoacyl tRNA synthetases as targets for new anti-infectives.

27 November 2018

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Cispentacin, a new antifungal antibiotic. II. In vitro and in vivo antifungal activities

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25489076

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25489076

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid A

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25489076

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1405994111

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25489076%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

ADS bibcode

2014PNAS..111E5508N

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25489076%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25489076

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25489076%20AND%20SRC:MED&resulttype=core&format=json