Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes (Q27932080)

positive regulation of exosomal secretion

GOA release 2020-03-11

1 reference

Putative acid anhydride hydrolase YOR291W

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

9

Peter A Lay

0 references

author name string

Stephanie M Y Kong

1

0 references

Brian K K Chan

2

0 references

Jin-Sung Park

3

0 references

Kathryn J Hill

4

0 references

Jade B Aitken

5

0 references

Louise Cottle

6

0 references

Hovik Farghaian

7

0 references

Adam R Cole

8

0 references

Carolyn M Sue

10

0 references

Antony A Cooper

Staging of brain pathology related to sporadic Parkinson's disease

11

0 references

language of work or name

English

0 references

publication date

1 June 2014

0 references

published in

Human Molecular Genetics

1 reference

1 December 2016

23

0 references

issue

11

0 references

page(s)

2816-33

0 references

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Pathogenic mutations in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Alpha-synuclein knockdown attenuates MPP+ induced mitochondrial dysfunction of SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Characterization of the P5 subfamily of P-type transport ATPases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

A comprehensive glossary of autophagy-related molecules and processes (2nd edition)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Autophagy as a regulated pathway of cellular degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of beta-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Cellular Zn2+ chelators cause "dying-back" neurite degeneration associated with energy impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Oxidative injury triggers autophagy in astrocytes: the role of endogenous zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Autophagy and multivesicular bodies: two closely related partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Exosomes--vesicular carriers for intercellular communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Active Wnt proteins are secreted on exosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Prion-infected cells regulate the release of exosomes with distinct ultrastructural features

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

ExoCarta 2012: database of exosomal proteins, RNA and lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Zinc coordination environments in proteins as redox sensors and signal transducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Zinc in the physiology and pathology of the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Mitochondrial inhibitor models of Huntington's disease and Parkinson's disease induce zinc accumulation and are attenuated by inhibition of zinc neurotoxicity in vitro or in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Zinc and cortical plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Microautophagy of cytosolic proteins by late endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

21 January 2018

When lysosomes get old.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Prion-like transmission of protein aggregates in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Uptake, distribution, and speciation of selenoamino acids by human cancer cells: X-ray absorption and fluorescence methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

EBV-gp350 confers B-cell tropism to tailored exosomes and is a neo-antigen in normal and malignant B cells--a new option for the treatment of B-CLL

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099

Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU099