Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease (Q36119653)

12 August 2017

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease (English)

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Gene Ontology release 2020-05-02

12 August 2017

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9

Harald Stenmark

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12 August 2017

Elizabeth M. C. Fisher

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object named as

Elizabeth M C Fisher

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12 August 2017

10

Anne Simonsen

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12 August 2017

Maria Filimonenko

1

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12 August 2017

Susanne Stuffers

2

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12 August 2017

Camilla Raiborg

3

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12 August 2017

Ai Yamamoto

4

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12 August 2017

Lene Malerød

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12 August 2017

Adrian Isaacs

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12 August 2017

Andreas Brech

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12 August 2017

language of work or name

English

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publication date

1 November 2007

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12 August 2017

16

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inferred from page(s)

published in

Journal of Cell Biology

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12 August 2017

179

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12 August 2017

3

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12 August 2017

485-500

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describes a project that uses

12 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2064794/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The emerging shape of the ESCRT machinery

2 October 2017

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Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy

2 October 2017

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LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization

2 October 2017

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

2 October 2017

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

2 October 2017

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Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease.

2 October 2017

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Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?

2 October 2017

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2 October 2017

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ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

2 October 2017

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2 October 2017

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The ESCRT complexes: structure and mechanism of a membrane-trafficking network

2 October 2017

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

2 October 2017

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

2 October 2017

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The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

2 October 2017

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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

2 October 2017

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Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major.

2 October 2017

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CHMP2B mutations are not a common cause of frontotemporal lobar degeneration

2 October 2017

1 reference

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

2 October 2017

1 reference

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Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

2 October 2017

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Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

2 October 2017

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Can autophagy protect against neurodegeneration caused by aggregate-prone proteins?

2 October 2017

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Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

2 October 2017

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LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

2 October 2017

1 reference

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

2 October 2017

1 reference

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A Unified Nomenclature for Yeast Autophagy-Related Genes

2 October 2017

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The Protein Network of HIV Budding

2 October 2017

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The prevalence and causes of dementia in people under the age of 65 years

2 October 2017

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STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes

2 October 2017

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Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting

2 October 2017

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The prevalence of frontotemporal dementia

2 October 2017

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SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation

2 October 2017

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Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates

2 October 2017

1 reference

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FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes

2 October 2017

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Impairment of the ubiquitin-proteasome system by protein aggregation

2 October 2017

1 reference

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Autophagy as a regulated pathway of cellular degradation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Vacuolar import of proteins and organelles from the cytoplasm

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Mutational analysis of Csc1/Vps4p: involvement of endosome in regulation of autophagy in yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

The autophagic and endocytic pathways converge at the nascent autophagic vacuoles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Autophagic vacuoles fuse with the prelysosomal compartment in cultured rat fibroblasts.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064794

Prelysosomal convergence of autophagic and endocytic pathways

23 September 2018

1 reference

12 December 2020

Frontotemporal dementia

1 reference

12 December 2020

CHMP2B mutations are not a cause of dementia in Dutch patients with familial and sporadic frontotemporal dementia

1 reference

12 December 2020

A Reassessment of the Neuropathology of Frontotemporal Dementia Linked to Chromosome 3

1 reference

12 December 2020

Alix regulates cortical actin and the spatial distribution of endosomes

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200702115

1 reference

12 August 2017

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12 August 2017

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