Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes (Q27933110)

MRX complex DNA-binding subunit YNL250W

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Venugopal Bhaskara

1

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Aude Dupré

2

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Bettina Lengsfeld

3

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Ben B Hopkins

4

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Angela Chan

5

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Ji-Hoon Lee

6

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Xiaoming Zhang

7

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Jean Gautier

8

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Virginia Zakian

9

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Tanya T Paull

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

10

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language of work or name

English

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publication date

9 March 2007

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1 reference

1 December 2016

25

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page(s)

647-61

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issue

5

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cites work

1 reference

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Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast

20 March 2017

1 reference

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes

20 March 2017

1 reference

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The rad50 signature motif: essential to ATP binding and biological function

20 March 2017

1 reference

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Yeast Xrs2 Binds DNA and Helps Target Rad50 and Mre11 to DNA Ends

20 March 2017

1 reference

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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

20 March 2017

1 reference

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

20 March 2017

1 reference

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

20 March 2017

1 reference

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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

20 March 2017

1 reference

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Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

20 March 2017

1 reference

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RAD50 protein of S.cerevisiae exhibits ATP-dependent DNA binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

20 March 2017

1 reference

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Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

20 March 2017

1 reference

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Recombination proteins in yeast

20 March 2017

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Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

7 April 2017

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Identification of the cystic fibrosis gene: genetic analysis

7 April 2017

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Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

7 April 2017

1 reference

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Depression of cell metabolism and proliferation by membrane-permeable and -impermeable modulators: role for AMP-to-ATP ratio.

7 April 2017

1 reference

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Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

29 September 2017

1 reference

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The ATP switch model for ABC transporters

29 September 2017

1 reference

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The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks

29 September 2017

1 reference

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Rap1p telomere association is not required for mitotic stability of a C(3)TA(2) telomere in yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early development

29 September 2017

1 reference

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ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

29 September 2017

1 reference

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Nucleoside monophosphate kinases: structure, mechanism, and substrate specificity

29 September 2017

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Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts

29 September 2017

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Overexpression, purification, and characterization of the SbcCD protein from Escherichia coli.

29 September 2017

1 reference

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A recombinant polypeptide model of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator functions as an active ATPase, GTPase and adenylate kinase.

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

P1,P5-Di(adenosine-5′)pentaphosphate, a Potent Multisubstrate Inhibitor of Adenylate Kinase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

Nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator, an ABC transporter, catalyze adenylate kinase activity but not ATP hydrolysis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

DNA breaks promote genomic instability by impeding proper chromosome segregation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3050042

Suppression of gross chromosomal rearrangements by the multiple functions of the Mre11-Rad50-Xrs2 complex in Saccharomyces cerevisiae

27 November 2018

1 reference

12 December 2020

Studies on adenine and adenosine metabolism by intact human erythrocytes using high performance liquid chromatography

1 reference

12 December 2020

Chromosome Fragmentation after Induction of a Double-Strand Break Is an Active Process Prevented by the RMX Repair Complex

1 reference

12 December 2020

The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres

1 reference

12 December 2020

Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere

1 reference

12 December 2020

RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability

1 reference

12 December 2020

10.1016/J.MOLCEL.2007.01.028

Identifiers

DOI

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701620

701620

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1 reference

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